ubiquitinates造句

• The APC Cdc20 complex ubiquitinates securin and targets it for degradation.
• PRC1 also mono-ubiquitinates histone H2A on lysine 119 ( H2AK119Ub1 ).
• Researchers found that Bmi-1 ubiquitinates ribonucleotide reductase M1 RRM1 for degradation.
• Cullin 3 ubiquitinates Nrf2, while Keap1 is a substrate adaptor protein that facilitates the reaction.
• When cIAP1 ubiquitinates RIP1 this molecule acts as a signal activating the canonical NF-?B signaling pathway.
• When securin, Cdc20, and E2 are all bound to APC / C E2 ubiquitinates securin and selectively degrades it.
• In cells that are infected with HIV, SCF ?TrCP interacts with Vpu and ubiquitinates CD4, which is subsequently degraded by the proteasome.
• The yeast homolog of CUL4A, Rtt101, ubiquitinates histone H3 and promotes nucleosome assembly and CRL4A complexes perform similar functions in human cells.
• Following depolarization of the mitochondria, PINK1 phosphorylates Miro at multiple sites, including S156, and Parkin ubiquitinates Miro, targeting it for proteasomal degradation.
• His lab discovered and purified many of the components involved in cell cycle progression, including anaphase promoting complex ( APC ), the complex that ubiquitinates cyclin B.
• Once the receptor and PA returns to the lipid raft, E3 ubiquitin ligase Cb1 ubiquitinates the cytoplasmic tail of the receptor, signaling the receptor and associated toxin proteins for endocytosis.
• The ubiquitin ligases ubiquitinates Notch and targets it for degradation Whatever the mechanism of Numb, the Notch receptor does not reach the nucleus and the transcription factors required for gliogenesis are not generated.