ubiquitinate造句

• Both CUL4A and its closely related homolog CUL4B may ubiquitinate histones H2A, H3 and H4.
• Additionally, TRIM32 is known to ubiquitinate dysbindin, a protein associated with both skeletal muscles and neural tissue.
• NEDD4 can bind and ubiquitinate the epithelial sodium channel ( ENaC ), leading to down-regulation of sodium channel activity.
• TRIM32 is expressed in skeletal muscle, where it interacts with myosin and may ubiquitinate actin ( it has been shown to do so in vitro ).
• NEDD4 has been shown to interact with and ubiquitinate the tumour suppressor protein PTEN " in vitro ", resulting in PTEN proteasomal degradation or trafficking.
• NEDD4-2 has been shown to ubiquitinate and therefore down regulate the epithelial sodium channel ( ENaC ) in the collecting ducts of the kidneys, therefore opposing the actions of aldosterone and increasing salt excretion.
• CSA and CSB are involved in transcription-coupled NER ( TC-NER ), which is involved in repairing DNA; they ubiquitinate RNA polymerase II, halting its progress thus allowing the TC-NER mechanism to be carried out.
• E3 ubiquitin ligase, consisting of SPOP and CULLIN3, is able to ubiquitinate the Polycomb group protein BMI1 and the variant histone MACROH2A . PRC1 is also recruited to the inactivated X chromosome in somatic cells in a highly dynamic, cell cycle-regulated manner.
• TRAF2 is required for TNF-alpha-mediated activation of MAPK8 / JNK and NF-?B . The protein complex formed by TRAF2 and TRAF1 interacts with the cIAP1 can ubiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis.
• NFE2L1 also interacts with another member of the SCF ligase ubiquitin family known as ?-TrCP . ?-TrCP also binds to the DSGLC motif, a highly conserved region of CNC-bZIP proteins, in order to poly-ubiquitinate NFE2L1 prior to its proteolytic degradation.
• The second ATM kinase phosphorylates the TQXF domain on MDC1 which allows it to recruit the E3 ubiquitin ligase RNF8, which will ubiquitinate the histones near the DSB which initiates further ubiquitination of the chromatin around the site of damage by other factors of the DDR . This aggregation of DDR factors and concentration of phosphorylated and ubiquitinated histones is called a DNA damage foci or ionizing radiation-induced foci and the main role of MDC1 is to coordinate the creation of DNA damage foci.