aauaaa造句

• CPSF-160 is the largest subunit of CPSF and directly binds to the AAUAAA polyadenylation signal.
• Most human polyadenylation sites contain the AAUAAA sequence, but this sequence is less common in plants and fungi.
• CPSF-73 is a zinc-dependent hydrolase which cleaves the mRNA precursor just downstream the polyadenylation signal sequence AAUAAA.
• CPSF1 recognizes the AAUAAA sequence leading to addition of poly ( A ) to the 3-prime end of the mRNA.
• CFI recognises a third site on the RNA ( a set of UGUAA sequences in mammals ) and can recruit CPSF even if the AAUAAA sequence is missing.
• When RNA polymerase II reaches a " termination sequence " ( TTATTT on the DNA template and AAUAAA on the primary transcript ), the end of transcription is signaled.
• They occur if polyadenylation signal sequence ( 5'- AAUAAA-3') is present in pre-mRNA, which is usually between protein-coding sequence and terminator.
• Furthermore, the 3'- UTR contains the sequence AAUAAA that directs addition of several hundred adenine residues called the poly ( A ) tail to the end of the mRNA transcript.
• The 3 & prime;-untranslated region may affect the translation efficiency of the mRNA or the stability of the mRNA . It also has sequences which are required for the addition of the poly ( A ) tail to the message, including the hexanucleotide AAUAAA.