zonulin造句

• In 2000, the research team of Alessio Fasano discovered zonulin, which regulates the intestinal permeability.
• Larazotide acetate ( previously known as AT-1001 ) is a zonulin receptor antagonist that has been probed in clinical trials.
• In 2014 a zonulin receptor antagonist, Larazotide acetate ( formerly known as AT-1001 ), completed a phase 2b clinical trial.
• Gliadin ( glycoprotein present in wheat ) activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.
• Larazotide acetate intervenes in the middle of this pathway by blocking zonulin receptors, thereby preventing tight junction disassembly and associated increase in intestinal permeability.
• Alternative treatments under investigation include the inhibition of zonulin, an endogenous signalling protein linked to increased permeability of the bowel wall and hence increased presentation of gliadin to the immune system.