zebularine造句

• The DNA methylation inhibitor Zebularine has also been studied, although results are currently inconclusive.
• Zebularine, an activator of a demethylation enzyme has also been used with some success.
• Some of the current DNMT inhibitors, however, like zebularine and procainamide, do not cross the blood brain barrier and would not prove as effective a treatment.
• For example, Zebularine, a demethylating agent, could be used to remove the methyl groups from the CpGs of the " dlc1 " promoter, thus increasing expression of DLC1 and helping to block tumor cell proliferation and metastasis.
• In a small study of mice with a defective " Adenomatous polyposis coli " gene, oral administration of zebularine to males had no effect on the overall methylation of DNA or the number of polyps, but in females the average number of polyps was reduced from 58 to 1.