ultrarapid造句

• These metabolizer types include poor, intermediate, extensive, and ultrarapid metabolizers.
• The occurrence of CYP2D6 ultrarapid metabolizers appears to be greater among Middle Eastern and North African populations.
• Ultrarapid metabolizers use amitriptyline much faster than extensive metabolizers; patients with this metabolizer type may have a greater chance of experiencing pharmacological failure.
• Ultrarapid metabolizers use nortriptyline much faster than extensive metabolizers; patients with this metabolizer type may have a greater chance of experiencing pharmacological failure.
• Guidelines released by the Clinical Pharmacogenomics Implementation Consortium ( CPIC ) advise against administering codeine to ultrarapid metabolizers, where this genetic information is available.
• KCNE3 can also regulate channels of the Kv3 subfamily, which are best known for permitting ultrarapid firing of neurons because of the extremely fast gating ( activation and deactivation ).
• The Clinical Pharmacogenetics Implementation Consortium recommends avoiding nortriptyline in persons who are CYP2D6 ultrarapid or poor metabolizers, due to the risk of a lack of efficacy and side effects, respectively.
• There are four phenotypes of CYP2D6 : Poor Metabolizer ( PM ), Intermediate Metabolizer ( IM ), Extensive ( normal ) Metabolizer ( EM ) and Ultrarapid Metabolizer ( UM ).
• Due to increased metabolism of codeine to morphine, ultrarapid metabolizers ( those possessing more than 2 functional copies of the CYP2D6 allele ) are at increased risk of adverse drug effects related to morphine toxicity.
• "Optical-mapping technology is a powerful platform for ultrarapid, high-resolution, whole-genome analysis that will find application in virtually every branch of biological science, " he said.
• Its woody, meaty sound and delicately picked, ultrarapid blues scales are his signature, but he has absorbed Wes Montgomery's jazz too and he stepped on a compressor pedal to pump out organlike octaves.
• They may last a few hours-" ultrarapid "-or extend over days-" ultradian " : clinicians maintain that only when four continuous days of hypomania, or seven days of mania, occur, is a diagnosis of bipolar disorder justified.
• For example, if CYP2D6 converts a drug that has a strong effect into a substance that has a weaker effect, then poor metabolizers ( weak CYP2D6 function ) will have an exaggerated response to the drug and stronger side-effects; conversely, if CYP2D6 converts a different drug into a substance that has a greater effect than its parent chemical, then ultrarapid metabolizers ( strong CYP2D6 function ) will have an exaggerated response to the drug and stronger side-effects.