ugt2b4造句

• These same bile acids are substrates for the UGT2B4 enzyme.
• Hence upregulation of UGT2B4 by activated FXR provides a mechanism for the detection, conjugation and subsequent elimination of toxic bile acids.
• The expression of the UGT2B4 enzyme is upregulated by the farnesoid X receptor ( FXR ), a nuclear receptor which is activated by bile acids.
• UGT2B4 is mainly involved in the glucuronidation of hyodeoxycholic acid, a bile acid, and catechol-estrogens, such as 17-epiestriol and 4-hydroxy-estrone.
• Both the UGT2B4 and UGT2B7 isoforms are able to glucuronidate HDCA . This is an example of redundancy in protection against harmful endogenous compounds provided by UGT isoforms, which present distinct but frequently overlapping substrate specificity.
• Together with UGT2B4, UGT2B7 is capable of glucosidation of hyodesoxycholic acid in the liver, but, unlike the 2B4 isoform, 2B7 is also able to glucuronidate various steroid hormones ( androsterone, epitestosterone ) and fatty acids.