uggt造句

• Currently, it is unclear how UGGT recognize misfolded glycoprotein.
• It has been proposed that UGGT may bind to exposed hydrophobic stretches, a characteristic feature of misfolded proteins.
• If the glycoprotein is still misfolded, UGGT will monoglycosylate it and allow the glycoprotein to go through the cycle again.
• UGGT is part of the ER quality control system of glycoprotein folding and its activity increases the potential for correctly folded glycoproteins.
• The main proteins involved in the ER quality control system are UGGT, the ER lectin chaperones ( calnexin and calreticulin ), and glucosidase II . UGGT first recognize the incompletely folded glycoprotein and monoglucosylate it.
• The main proteins involved in the ER quality control system are UGGT, the ER lectin chaperones ( calnexin and calreticulin ), and glucosidase II . UGGT first recognize the incompletely folded glycoprotein and monoglucosylate it.
• The ER is capable of recognizing misfolding proteins without causing disruption to the functioning of the ER . The aforementioned sugar molecule remains the means by which the cell monitors protein folding, as the misfolding protein becomes characteristically devoid of glucose residues, targeting it for identification and re-glycosylation by the enzyme UGGT ( UDP-glucose : glycoprotein glucosyltransferase ) 1.