tauopathy造句

• AD is also considered a tauopathy due to abnormal aggregation of the tau protein.
• Neurofibrillary tangles were first described by Alois Alzheimer in one of his patients suffering from Alzheimer's disease ( AD ), which is considered a secondary tauopathy.
• Huntington's disease : a neurodegenerative disease caused by a CAG tripled expansion in huntingtin gene is the most recently described tauopathy ( Fernandez-Nogales et al.
• In particular, studies using a tauopathy mouse model confirmed that disease-causing tau mutations can cause cell cycle abnormalities in mammalians ( Delobel et . a, 2006 ).
• AD is also considered a tauopathy due to abnormal aggregation of the tau protein, a microtubule-associated protein expressed in neurons that normally acts to stabilize microtubules in the cell cytoskeleton.
• In addition, apolipoprotein AII amyloid can be induced in mice by a variety of ?-sheet rich amyloid fibrils, and cerebral tauopathy can be induced by brain extracts that are rich in aggregated A?.
• Postmortem diagnosis provides the only true indication of the presence of CBD . Most of these diagnoses utilize the Gallyas-Braak staining method, which is effective in identifying the presence of astroglial inclusions and coincidental tauopathy.
• For example, in addition to tauopathy and A?-amyloidosis ( which coexist as key pathologic features of Alzheimer's disease ), many Alzheimer patients have concomitant synucleinopathy ( Lewy bodies ) in the brain.
• The four clinical stages of observable CTE disability have been correlated with tau pathology in brain tissue, ranging in severity from focal perivascular epicentres of neurofibrillary tangles in the frontal neocortex to severe tauopathy affecting widespread brain regions.
• Dawson, Hana N .; Viviana Cantillana, Liling Chen, and Michael P . Vitek ( 2007 ) . " The Tau N279K Exon 10 Splicing Mutation Recapitulates Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Tauopathy in a Mouse Model ".
• "' Primary age-related tauopathy "'( "'PART "') is a new neuropathological designation used to describe the neurofibrillary tangles that are commonly observed in the brains of elderly individuals that can occur independently of the amyloid plaques of Alzheimer's disease.
• There is now evidence that other proteopathies can be induced by a similar mechanism, including A? amyloidosis, amyloid A ( AA ) amyloidosis, and apolipoprotein AII amyloidosis, tauopathy, synucleinopathy, and the aggregation of superoxide dismutase-1 ( SOD1 ), polyglutamine, and TAR DNA-binding protein-43 ( TDP-43 ).