limk1造句

• LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.
• Pyr 1 is a cell permeable competitive inhibitor of Lim Kinase ( especially LIMK1 ).
• LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development.
• LIMK1, an actin binding protein, phosphorylates ADF / cofilin, allowing for the formation of F-actin.
• ADF / cofilin proteins are inactivated by kinases such as LIM domain kinase-1 ( LIMK1; MIM 601329 ).
• LIMK1 knockout neurons are unable to form a cytoskeletal matrix within the dendritic spine, which has interesting implications for learning.
• It is a high degree protein temporal controller, as it is able to interact in a few minutes or even seconds with molecules such as LIMK1.
• In the presence of Pyr1, LIMK1 is inhibited, which means that the phosphorylation of cofilin decreases, which results in the blockage of the regulation of actin microfilaments dynamics and, therefore, the disorganization of microfilaments.
• In addition to other mechanisms, PAK4 functions are mediated though phosphorylation of its effector proteins, including, LIMK1-Thr508, integrin ?5-Ser759 / Ser762, p120-catenin-Ser288, superior cervical ganglia 10 ( SCG10 )-Ser50, GEF-H1-Ser810 ?-catenin-Ser675,
• In the transient stage, the signaling cascade caused by synaptic activity results in LIMK1 phosphorylating ADF / cofilin via both the RhoA and Cdc42 pathways, which in turn inhibits the depolymerization of F-actin and increases the volume of the dendritic spine drastically while also inducing LTP . Murakoshi, Wang, and Yasuda ( 2011 ) examined the effects of Rho GTPase activation on the structural plasticity of single dendritic spines elucidating differences between the transient and sustained phases.