laptm4b造句

• Elevated LAPTM4B level contributes to chemotherapy resistance in breast cancer.
• Increased expression of LAPTM4B has been found in breast, liver, lung, ovarian, uterine, gastric cancers.
• In 2011, the same group reported that LAPTM4B also promotes autophagy, a cell survival mechanism mediated by lysosomes.
• LAPTM4B promotes autophagy and renders tumor cells resistant to metabolic and genotoxic stress and results in more rapid tumor growth.
• Based on these findings, LAPTM4B can be utilized to be a therapeutic target to prevent chemotherapy resistance or a marker to identify the patients who will not benefit from anthracyclines.
• It was found that overexpression of LAPTM4B causes anthracyclines ( doxorubicin, daunorubicin, and epirubicin ) resistance by retaining drug in the cytoplasm and decreasing nuclear localization of drug and drug induced DNA damage.