cyclosome造句

• When anaphase onset is triggered, the anaphase-promoting complex ( "'APC / C "'or Cyclosome ) degrades securin.
• The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex / cyclosome ( APC / C ), delaying the onset of anaphase and ensuring proper chromosome segregation.
• A large protein complex, termed the anaphase-promoting complex ( APC ), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome.
• This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex / cyclosome ( APC / C ), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination.
• The anaphase-promoting complex or cyclosome ( APC / C ) controls the metaphase anaphase transition when bound to its substrate-specific activating subunit Cdc20 : this complex ubiquitinylates the separase-inhibiting protein securin, paving the way for separase to break cohesin and thus separate the sister chromatids at the centromere.