cyclopamine造句

• A water-soluble cyclopamine may be more effective in cancer treatment.
• Sonic hedgehog blockers are available, such as cyclopamine.
• It is the molecular target of the teratogen cyclopamine.
• Chemically, it is a semi-synthetic derivative of the alkaloid cyclopamine.
• One example is the alkaloid cyclopamine, produced in the leaves of corn lily.
• Studies suggest that cyclopamine acts as a primary inhibitor of the hedgehog signaling pathway in cells.
• The cyclopamine derivative IPI-926 is in clinical trials for the treatment of various types of cancer.
• Hedgehog interacting protein or cyclopamine, the first two are protein and the last a small molecule . ]]
• A way of controlling the pathway using cyclopamine could turn this problem on its head and provide a way to treat cancer.
• Cyclopamine was named for one-eyed lambs which were born to sheep which grazed on wild corn lily at a farm in Idaho.
• "' Cyclopamine "'( 11-deoxojervine ) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids.
• Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
• In 1957 the US Department of Agriculture started an eleven-year investigation which led to the identification of cyclopamine as the cause of the birth defect.
• After decades of research, in the 1980s, the compound responsible for these deformities was identified as the alkaloid 11-deoxyjervine, later renamed to cyclopamine.
• Similar to cyclopamine, which also occurs in the " Veratrum " genus, it is a teratogen implicated in birth defects when consumed by animals during a certain period of their gestation.
• In further studies with mice, an inhibitor of the SHH pathway ( cyclopamine drug ) was sufficient to reduce proliferation of tumour cells that had been infected with a retro virus encoding mir-17-92 ( plus a GFP reporter ).
• The process begins with cyclopamine extracted from harvested Veratrum californicum which is taken through a series of alterations resulting in an analogue of the natural product cyclopamine, making IPI-926 the only compound in development / testing that is not fully synthetic.
• The process begins with cyclopamine extracted from harvested Veratrum californicum which is taken through a series of alterations resulting in an analogue of the natural product cyclopamine, making IPI-926 the only compound in development / testing that is not fully synthetic.
• "Veratrum album ", or white hellebore, an herbal medicine described by Hippocrates before 400 BC, contains the alkaloids cyclopamine and jervine, which are teratogens capable of causing cyclopia and holoprosencephaly, severe birth defects in which a fetus can be born with a single eye.