corneocytes造句

• Corneocytes will eventually be shed off through desquamation as new ones come in.
• Those junctions disintegrate as corneocytes migrate toward the surface of the skin and result in desquamation.
• Corneocytes are keratinocytes that have completed their differentiation program and have lost their nucleus and cytoplasmic organelles.
• These corneocytes are embedded in a lipid matrix composed of ceramides, cholesterol, and fatty acids.
• Corneocytes in the lower part of the stratum corneum are bridged together through specialized junctions ( corneodesmosomes ).
• Corneocytes are embedded in a matrix of specialized lipids that constitute approximately 20 % of the stratum corneum volume.
• Proteolysis of corneodesmosomes is required for desquamation, the shedding of corneocytes from the outer layer of the epidermis.
• As corneocytes are essentially dead cells, they are not prone to viral attacks, though invisible microabrasions may cause permeability.
• Corneocytes are also capable of absorbing and storing small amounts of water to keep the skin hydrated and maintain its flexibility.
• Concomitantly, cells lose their nuclei and organelles causing the granular cells to become non-viable corneocytes in the stratum corneum.
• Corneocytes contain small molecules called natural moisturizing factors, which absorb small amounts of water into the corneocytes thereby hydrating the skin.
• Corneocytes contain small molecules called natural moisturizing factors, which absorb small amounts of water into the corneocytes thereby hydrating the skin.
• The lipids ultimately form the lamellar lipid bilayer that surrounds corneocytes and also contribute to permeability barrier homeostasis of the stratum corneum.
• Layers of corneocytes produce high mechanical strength which allow epidermis of the skin to perform its function as a physical, chemical and immunological barrier.
• For example, corneocytes act as UV barrier by reflecting the scattered UV radiation, protecting cells inside the body from apoptosis and DNA damage.
• Three adhesive proteins desmoglein-1, desmocollin-1 and corneodesmosin compose the corneodesmosomes and provide the cohesive forces to connect the adjacent corneocytes.
• Major constituents of corneocytes are keratin intermediate filaments organized in parallel bundles to form a matrix to give rigidity to the overall structure of the skin.
• The components of the corneodesmosomes are gradually degraded by the enzymes that digest proteins, as the corneocytes are pushed towards the surface of the skin.
• These hydrophobic components fuse together to form multiple bilayers of lipids between corneocytes to act as the principal barrier to the transcutaneous movement of water and electrolytes.
• As a result of the weakened corneodesmosomes in the outer skin surface, the uppermost layers of corneocytes get exfoliated through frictional forces such as rubbing or washing.