azapirones造句

• However, azapirones are considered less effective with slow onset in controlling symptoms.
• On a pharmacological level, azapirones varyingly possess activity at the following receptors:
• Unlike benzodiazepines, azapirones lack abuse potential and are not tolerance or physical dependence.
• Metabolism of azapirones occurs in the liver and they are excreted in urine and feces.
• "' Azapirones "'are a class of drugs used as anxiolytics and antipsychotics.
• Azapirones have more tolerable adverse effects than many other available anxiolytics, such as benzodiazepines or SSRIs.
• Additionally, many azapirones are also pyrimidinylpiperazines, though again this does not apply to them all.
• Actions at 5-HT 7, and sigma receptors have also been shown for some azapirones.
• Azapirones are poorly but nonetheless appreciably extended release formulation of gepirone is currently under development and if approved, should help to improve this issue.
• It is closely related to several other piperazines, including eltoprazine and batoprazine, and TFMPP, as well as more distantly to the azapirones such as buspirone.
• However, despite all being called azapirones, not all of them actually contain the azapirodecanedione component, and most in fact do not or contain a variation of it.
• A common metabolite of several azapirones including buspirone, gepirone, ipsapirone, revospirone, and tandospirone is 1-( 2-pyrimidinyl ) piperazine ( 1-PP ) . 1-PP possesses 5-HT 1A partial agonist and ? 2-adrenergic antagonist actions and likely contributes overall mostly to side effects.