adozelesin造句

• "' Adozelesin "'is an experimental antitumor drug of the duocarmycin class.
• Despite similar abilities to alkylate DNA, adozelesin and bizelesin caused a decrease in HCT116 tumor cell proliferation by different pathways.
• This research has led to synthetic analogs including adozelesin, bizelesin, and carzelesin which progressed into clinical trials for the treatment of cancer.
• However, in cells lacking p21, bizelesin, as well as adozelesin, triggered apoptosis, indicating that p21 was crucial to sustained bizelesin-induced G ( 2 )-M arrest.
• Adozelesin and bizelesin cause genomic DNA lesions by alkylating DNA . Adozelesin induces single-strand DNA lesions, whereas bizelesin induces both single-strand lesions and double-strand DNA cross-links.
• Adozelesin and bizelesin cause genomic DNA lesions by alkylating DNA . Adozelesin induces single-strand DNA lesions, whereas bizelesin induces both single-strand lesions and double-strand DNA cross-links.
• Low adozelesin concentrations ( e . g ., 0.5 nM ) induced a transient S-phase block and cell cycle arrest in G ( 2 )-M, as well as increased induction of p53 and p21, whereas a high drug concentration ( e . g ., 2.5 nM ) caused apoptosis but no p21 induction.