The analysis on the 5 " flanking region revealed tata box , putative api and nur77 response elements , prl and progesterone response elements motifs related with regulation on 20ahsd gene expression 通过软件对克隆到的5侧翼区结构和功能分析，发现了20 hsd基因的tatabox 、 prl反应元件、类固醇激素反应元件、 ap1和nur77等转录因子结合位点。
The electrochemistry investigation of the binding mode of eu3 + - rutin complex to dna the interaction of the eu3 + - rutin complex by dna is studied . studies involved the interaction of the eu3 + and rutin , eu3 + - rutin complex and dna 这些参数为eua气rutin酉己合物与d a结合时结合力的强弱，结合位点的多少提供了参考，有助于评估它的抗癌活性。
It is show the mutant consists of a nuclei binding site and dna - binding domain is enough to negative regulation . a report plasmid pcat that we constructed has a cat gene expressed by a cmv early promoter （ 465 1079氨基酸段）对sv40启动子明显的抑制活性，因为它只包含dna结合域和核结合位点，说明发挥转录抑制功能的关键是ie180的dna结合域。
Advances in antibody engineering make it possible to produce various recombinant proteins that exploit the specificity of the antibody - combining site to manipulate tumour - related signalling , and to stimulate anti - tumour immune responses 抗体工程的进展使得制造不同的重组蛋白成为可能，而这些重组蛋白可以利用抗体结合位点的特异性来操纵肿瘤相关信号及刺激抗肿瘤免疫反应。
These analyses suggest that the incorporation of mrna decay rates and the use of the inferred transcription rates can facilitate the study of gene regulations and the reconstruction of transcriptional regulatory networks 因而，如果要研究转录因子的目标基因，运用转录率可以得到更为准确的基因聚类。在寻找dna结合位点模体研究中，我们运用reduce算法结合mrna转录率和基因上游序列。
Like calmodulin and troponin c , caltractin contains four potential calcium - binding sites of predicted helix - loop - helix or ef - hand structure . with the development of technology in biology , more and more academicians study questions for discussion by mutating genes in organisms 中心蛋白的结构类似于钙调蛋白、肌钙蛋白c的结构，含有四个ef - hand ( helix - loop - helix )结构，即四个钙结合位点。
The 7mer peptide and 12 mer peptide selected from the peptide library elicited strong anti - vegf antibody immuno - reaction in mice . dna sequenseing showed that gwyydal and vasavfysalve mimic the discontinuous epitope of vegf by the 14 - 17 , 21 and 21 25 amino acid residues respectively 两者可能分别模拟了vegf分子的21 、 25位氨基酸和14 、 17 、 21位氨基酸通过折叠后在三级结构水平上形成的结合位点和vegf竞争结合受体。
2073 bp fragment of rubisco was cloned , sequenced and analyzed from a . platensis fachb341 , including partial sequence of rbcl gene , rbcx gene and rbcs gene . there are two transcription stem - loop termination structures downstream of the 3 " sequence of rbcl gene 分析结果显示此基因的结构如下： 11230hp为rbcl基因； 1362 1727hp为rbcx基因； 1776 2073hp为rbcs基因： rbcl和rbcx基因之间存在rbcl基因的两个转录茎环结构， 1732上为核糖体结合位点ggag 。
Extension of low k + treatment to 12 hours did not increase the binding sites or protein abundance either . among ros species , h2o2 was specifically involved in the up - regulation of na , k - atpase induced by low k . 96 base pairs of upstream of na , k - atpase subunit promoter was the key cis - element in transcriptional regulation of promoter activity Ros对钠钾atp酶亚基启动子的刺激作用缩小至编码区上游96碱基对，该序列包含多个潜在sp1转录因子结合位点，研究也表明sp1参与了低钾对钠钾atp酶的调节作用。
Glial cell line - derived neurotrophic factor ( gdnf ) was originally isolated based on its potent and specific ability to promote the survival and morphological differentiation of dopaminergic neurons and motoneurons in embryonic midbrain cultures . in addition , gdnf also support the survival and regulate the differentiation of many peripheral neurons , including sympathetic , parasympathetic , sensory and enteric neurons . gdnf also plays a crucial role outside the nervous system , as a morphogenetic factor in kidney development and as a regulator of spermatogonia differentiation Gfr 1与gdnf结合位点的研究胶质细胞源性神经营养因子( gdnf )对多巴胺能神经元、运动神经元、感觉神经元、肠道神经元等多种神经元具有促进存活及保护作用，它还能促进肾脏的发育和精原细胞的成熟，因此，极有希望用于治疗神经损伤和神经系统退行性病变。
