细胞周期 cell cycle: dna damage checkpoints; cell cycle: mitotic checkpoint; cell cycle:control of entry and progression through s phase; cell-cycle; generation cycle
Cyclins regulatory proteins whose concentration varies with certain stages of the cell cycle 细胞周期蛋白:在细胞周期的各个阶段发生变化的调控蛋白。
Cyclins help control progress through the various stages of the cell cycle by activating protein kinases ( cyclin - dependent protein kinases ) 它可以通过激活蛋白激酶来调节细胞周期中各个阶段的进行(细胞周期蛋白依赖性的蛋白激酶) 。
Cyclins are important proteins in regulating cell cycle , which form the holo - enzyme complex with cdk as a triggering factor in the cell cycle , the assembly and activation , degradation of cyclin - cdk holo - enzyme complex is the main molecular basis of cell cycle regulation 细胞周期蛋白( cyclin )是调节细胞周期活动的重要蛋白质,它们与细胞周期蛋白依赖性激酶( cyclindependentkinase , cdk )共同形成的全酶复合体是细胞周期的正性驱动分子。
All different cyclins found in mammalian cells contain a 100 amino - acid homologous region named cyclin box , which is the molecular structure marker of cyclins . the expression level of cyclins shows cell cycle phase specialty . it can be regulated by transcription and the degree of protein hydrolysis 在哺乳动物细胞发现的12型细胞周期蛋白中均含有一段由100个左右氨基酸组成的保守区,称为周期蛋白盒( cyclinbox ) ,它是细胞周期蛋白的分子结构标志。
They are positive regulating proteins and play a very important role in the development of neoplasma . cki are negative regulators taking part in cell cycle , which can directly or indirectly combine with the corresponding cdks to inhibit their activity . cyclin - cdk - cki constitutes a complex network regulating cell cycle 细胞周期蛋白依赖性激酶抑制因子( cyclindependentkinaseinhibitors , cki )可直接抑制相应的cdk活性或通过与cyclin竞争性结合cdk而起到抑制cyclin - cdk复合物的活性,从而作为负性调节因子参与细胞周期调控。
Nh2 terminus lacks a " destruction box " that controls the ubiquitin - dependent degration but contains an epithdermal growth factor receptor - like autophosphorylation sequence in addition to cyclin box . the structure hints that it is not only a cyclin in cell cycle regulation but also an intracelluar signal transducer molecule . cycg has not yet been matched with a cdk binding partner , and it ' s biologic function is still elusive G型蛋白是细胞周期蛋白家族中的新成员,它的分子结构与多数cyclin有所不同,其n端缺少降解所需的“ destructionbox ”氨基酸序列,而c末端却包含有与表皮生长因子受体相似的自主磷酸化位点,这些表明它既是一种细胞周期蛋白,也是细胞内的信号传导分子。
Introduction protein kinase c ( pkc ) is a number of serine / threonine kinase family which play central regulatory roles in a multitude of cellular processes , including cell proliferation , cell cycle progression , differentiation , apoptosis . increasing evidence from studies using in vitro and in vivo systems suggests that pkc is a key regulator of critical cell cycle transitions , including cell cycle entry and exit and the gl and g2 checkpoint 前言细胞周期是细胞增殖、分化的一个重要过程,它的启动与进程受到严格调控,参与调控的因子不仅包含起正调控作用的细胞周期素( cyclins ) 、细胞周期蛋白依赖性激酶( cyclin - dependentkinase , cdk ) 、还有起负调控作用的cdk抑制因子( cyclin - dependentkinaseinhibitor , cki ) 。