集落刺激因子

• Cd 14 * monocytes or bone marrow derived hematopoietic progenitor cells cultured with granulocyte - macrophage colony - stimulating factor ( gm - csf ) and il - 4 differentiate into efficient apc with morphology and cell surface molecule expression typical of immature dc . it was demonstrated that a variety of factors ( such as lps , tnf - a , il - 1 , monocyte - conditioned medium , and cd40 receptor cross - linking ) induce the maturation of immature dc to mature dc that are much more potent in activating t cells by increasing the expression of costimulatory molecules and cytokines , promoting the migration of dc to draining lymph nodes , and down - regulating the capacity of dc to capture and process antigen
  在体外，外周血cd14 ~ +单核细胞和cd34 ~ +骨髓造血前体细胞在粒细胞-巨噬细胞集落刺激因子( granulocyte - macrophagecolony - stimulatingfactor , gm - csf )和il - 4的共同作用下可分化为未成熟dc ，未成熟dc具有强大的摄取和处理抗原的能力，但其抗原提呈能力较弱；未成熟dc在炎性细胞因浙江大竿俗士学位论文潜廷平子汐ilq ， yfax病原成分汐lpsx单核细胞条件培养液或cd40l等作用下可分化为成熟dc 。