" the concept is that systemic sclerosis , which is a seere disease characterized by systemic fibrosis , is at the beginning mainly a ascular disease , and we hypothesize that using major ascular drugs ( calcium channel blockers , endothelin antagonists , prostacyclins , phosphodiesterase inhibitors , etc . ) from the beginning and at appropriate dosage may interfere with the fibrotic process which seems secondary , " dr “从概念上讲，系统性硬化是一种以系统性的纤维化变性为特征的严重疾病，早期主要表现在血管性的病变，因此我们推测早期、适量地应用主要作用于血管的药物（如钙离子阻断剂，内皮素拮抗剂，前列环素，磷酸二酯酶抑制剂等）可能可以干预似乎是继发发生的纤维化过程。 ”
On the conventional whole cell patch clamp mode . howevef , under the perforated whole cell patch clamp mode , l00 ll m snp caused a efficient increase in ik ( . . ) by 20 ' 2 % t4 . 5 % at 60mv 4 - ap l0 mm , a kind of selective inhibiter of delayed rectifier potassium current [ ik ( v ) ] , can not inhibit the snp - induced increase of ik ( c . ) 应用相同的刺激模式，一在传统全细胞模式下s pnovm 0卜m于m00vm对ik （ c一尤影啊… o仍）然而在穿孔模式下当细胞膜去极化至均0 v时， 1皿卜m p可明显增加人0川达zo二士牛5 … 8厂选择性延迟整流型钾电流阻断剂10mm个ap不能抑制snp对ik （ c 。
