P - catenin had similar changes as p120ctn . cells become thin and long and irregular in morphology after phosphorylation of p120ctn , but this situation was improved after cells transfected exogenous p120ctn isoform 3a , but it became worse while transfacted plus egf stimulation for p120ctn abundantly translocated into nucleus , cell behavior became more invasive . interestingly , we found p - catenin nucleus expression reduced and " returned " to cytoplasm and membrane in some 而p120ctn和p一连环蛋白在细胞内的分布也发生改变，表现为以胞膜和胞浆表达为主，胞核表达减弱，即芒果贰具有降低由egf引起的细胞恶性生物学特征，其机制可能与抑制酪氨酸蛋白激酶有关，但尚需进一步研究证实。
