酪氨酸激酶

• A search by profscan program showed that some predicted modification sites including four protein kinase c phosphorylation sites , three casein kinase ii phosphorylation sites and so on distributed over the protein sequence of trptl
  此外，在整个氨基酸序列中，还有4个蛋白激酶c磷酸化位点、 3个酪氨酸激酶位点等不同的修饰位点。
• Sorafenib , a novel , oral multi - kinase inhibitor , targets on serine / threonine and receptor tyrosine kinases of the tumor cells and vasculature ; blocks the signal transconduction and inhibits tumor growth
  摘要索拉非尼是首个口服多激酶抑制药，靶向作用于肿瘤细胞和肿瘤血管上的丝氨酸和（或）苏氨酸及受体酪氨酸激酶，阻断信号传导，抑制肿瘤生长。
• The neurotrophic and morphogenic activities of gdnf are mediated by its interaction with a multicomponent receptor complex formed by the ret receptor tyrosine kinase and a glycosylphosphatidylinositol ( gpi ) - anchored " accessory " receptor , gdnf family receptor alpha - 1 ( gfral )
  Gdnf的神经营养作用主要是通过两类受体亚基介导，即胶质细胞源性神经营养因子受体alpha ( gfr s )亚基和受体酪氨酸激酶ret亚基。
• Pka , receptor tyrosine kinase ( trk ) and classical nuclear receptor of gc were not involved in the gc " s activation of mapks the second part studied the nuclear translocation of gc activated mapks , mainly p38 and jnk , with laser confocal microscopy . the results showed that : 1
  Gc激活的mapks的激活不需要pka酪氨酸激酶受体trk及经典gc核受体的参与第二部分是研究gc激活的mapks的核转位，主要是p38和jnk ，用激光共聚焦显微镜观察到以下结果： 1
• Trka , the high affinity ngf receptor , contains an intracellular domain with tyrosine kinase activity and an extracellular domain with three tandem leucine - rich motifs flanked by two cysteine clusters in their amino termini and two immunoglobulin - like domains in the more membrane - proximal region
  膜外域含有8个亮氨酸的重复区域，其前后分别串联着一组半胱氨酸残基，紧挨细胞膜的是两个c2 -型免疫球蛋白样区ig和ig ；膜内域为酪氨酸激酶催化活性区。
• Northern blot results show that nos . 66 - 1 , 84 , 89 - 1 , 97 , 108 , 152 , 175 and 233 have stronger signal in sp6 - tester than in sp6 - driver ; and no . 23 has weak signal only in sp6 - tester , nos . 94 , 165 , 172 , 185 and 191 have similar hybridization signals in both sp6 - tester and sp6 - driver ; nos . 4 , 17 , 18 , 28 , 6 9 , 101 , 156 - 1 , 157 - 1 and 183 do not reveal hybridization signals in both sp6 - tester and sp6 - driver ; the results of sequencing and blastn and blastx on ncbi indicate that no . 23 cdna ( 846bp ) has significant alignments with nicotiana tabacum mrna for elicitor inducible beta - 1 - glucanase nt - sube76 , and arabidopsis thaliana clone 7119 for glycosyl hydrolase family 17 ( protein id : at5g55180 . 1 , supported by cdna : 7119 , supported by cdna : gi _ l 87001 54 ) and arabidopsis thaliana beta - 1 - glucanase - like protein ( gi _ 2 1594590 ) ; no . 84 cdna ( 560bp ) has significant alignment with lotus corniculatus aspartate aminotransferase mrna ( complete cds length = 1685 , gi | 2605931 | gb | af029898 . 1 | af029898 ) for aspartate aminotransferase ; no . 89 - 1 cdna has significant alignment with arabidopsis tha
  与同源性最高的拟南芥类似晚期胚胎发生高丰度蛋白比较，二者都具有lea 2结构域、保守分泌蛋白cog5608结构域和低复杂度区，都具有pkc磷酸化位点、酪蛋白激酶磷酸化位点、 n十四酞化位点和酚胺化位点，所不同的是： （ ）在结构功能域上， 152全长cdna编码的蛋白质序列中多了1个lea 2结构域、 l个保守分泌蛋白cog5608结构域和1个低复杂度区； （ 2 ）在功能位点上， 152全长cdna编码的蛋白质具有酪氨酸硫酸化位点、多了l个酪氨酸激酶磷酸化位点和1个可能的天冬氨酸富集区，但没有n糖基化位点； （ 3 ）拟南芥类似晚期胚胎发生高丰度蛋白的lea 2结构域具有显著性（ e
• It has been demonstrated that kvl . 2 , an isoform of delayed - rectifier potassium channel , is up - regulated in the ischemic neurons . besides , the activity of kvl . 2 is tyrosine phosphorylation dependent , phosphorylation of the tyrosine residue in the amino terminus of the channel by tyrosine kinases suppresses the channel current . therefore , we hypothesize that vegf could enhance the phosphorylation of kvl . 2 , which results in an inhibition of / k
  在介导i _ k的钾通道家族中， kv1 . 2是其中的一个亚型，研究报道它在缺血神经元中的表达是增高的；此外，它的活性与其酪氨酸磷酸化水平相关，在其氨基末端的酪氨酸残基经酪氨酸激酶磷酸化后可显著降低其介导的电流的幅度。
• The cyst cells enclosing spermatomeres maybe synthesize a kind of scf - like protein , which can recognize specially the c - kit receptor on the cellular membrane of spermatomeres . then c - kit is activated , dimerizing and autophosphorylating . at the same time , the tyrosine kinase domain of c - kit is activized , which phosphorylates the proteins that have sh2 domain
  精母细胞周围的囊细胞可能合成scf样蛋白，特异地识别精母细胞膜上的c - kit受体，并刺激c - kit发生二聚化、自体磷酸化，激活胞内酪氨酸激酶活性，活化具有“ sh _ 2结构域”的靶蛋白，可能通过一系列信号级联，最终激活与减数分裂的相关蛋白或基因。
• Objective : flt - 3 ligand ( fins - like tyrosine kinase receptor - 3 ligand , fl ) was a recently described growth factor affecting early hematopoietic progenitor cells , that play a key role in the growth and differentiation of primitive hematopoietic cells . fl promotes the survival , proliferation , and differentiation of hematopoietic progenitors in synergy with other growth factors
  Fms样酪氨酸激酶受体3配体( fms - liketyrosinekinasereceptor - 3ligand ， fl )是一种新近发现的、能够有效地刺激早期造血的细胞因子，可单独或联合其他细胞因子促进造血干细胞的增殖。
• Ngf binding to trka receptors results in receptor dimerization and kinase activation . recent evidence supports that not all extracellular subdomains are responsible for receptor activation . structure based drug design for neurotrophic agonists with small molecular weight relies on knowledge of the interaction of neurotrophin with their receptors
  Trka在ngf作用下发生二聚化，使胞内域中酪氨酸激酶区激活，从而使trka中酪氨酸自磷酸化，并进一步激活胞内信号转导通路，从而实现神经营养信号传递。