Main outcome measures : surial free of major aderse cardiac eents defined as cardiac death , nonfatal mi , and / or symptom - drien reascularization 主要结果量度：无主要严重心脏意外（定义为心脏死亡、非致命的mi和/或症状驱动的血管形成术）的生存期。
Airway remodelling refers to changes in the airway structure and includes subepithelial fibrosis , increased smooth muscle mass , submucosal gland enlargement , neovascularisation and epithelial alterations 气道重构指气道结构的改变，包括：上皮下纤维化，平滑肌增厚，粘膜下腺体肥大，新生血管形成和上皮的变化。
During embryogenesis , capillaries develop in the fetus by neovascularization , where endothelial cells arise from progenitor cells ; and angiogenesis , in which new blood vessels sprout from old ones 在胚胎发育期，胎儿通过新血管化过程（其内皮细胞源于祖细胞）和新生血管形成过程（新血管由旧血管芽生而来）生成毛细血管。
In this manner , angiostatin inhibits the growth of primary and metastatic tumors in vivo . it is a promising drug for angiogenesis - dependent diseases especially in pre - clinical and clinical cancer trials As可以阻抑血管生成治疗由病理性血管形成而导致的疾病，尤其是可通过抗肿瘤新生血管生成抑制肿瘤的生长与转移，有重要的临床应用价值。
Considering the lack of efficiency or the side effects of synthetic antiangiogenic drugs at clinical trials , down - regulation of hypoxia - induced angiogenesis by use of naturally occurring functional foods may provide an effective means of prevention 考虑到缺乏合成抗血管形成药物的有效率及副作用临床实验的数据，使用食物来下调缺氧诱导血管生成是一个积极的预防方式。
Recent advances in biomedical research , such as vascular growth factors , clonality of hemangioma endothelial cells , immunophenotype , endothelial progenitor cells ( epcs ) , somatic mutations of ih , provide insights into a deeper understanding of the etiology of the tumor of childhood 近年来对与该病相关的血管形成生长因子、单克隆生长、免疫表型、内皮祖细胞、基因缺陷等多方面进行了较深入的研究。
But now , in work about to be published in the " journal of cellular biochemistry " , a team of portuguese scientists shows that progesterone seems to sustain the formation of blood vessels , which , by supplying nutrients to the tumour cells , are vital for breast cancer progression 将要发表在《细胞生物化学杂志》上的一项研究中，葡萄牙科学家组成的研究小组表示，孕酮能维持血管形成，后者为肿瘤细胞提供营养，是乳癌演进的关键。
Section two the evaluation of biocompatibility of the acellular dermal matrix by the method of cell culture . the new born rat ' s epdermic cells were cultured with the acellular dermal matrix together as experiment group , while the epdermic cell were cultured simply as control . 24 hours later , under the invert microscope , the epidermic cells anchored well and transparent flat cells were observed in both groups . 7 days later , both cultured cells were taked out and fixed in 95 % ethanol , stained with hematoxylin and were observed under light microscope . many cleaved cells were observed in both groups . during cell culture , no pathogenic microganism was observed . so we considered the acellular dermal matrix was aseptic and had good biocompatibility . section three subdermal implantation of the acellular dermal matrix . 24 rats were used in the experiments . a piece of acellular dermal matrix ( 1 . 5 x 1 . 5cm2 ) was implanted beneath the dorsum skin flaps of each rat , 1 week , 2 weeks , 3 weeks and 4 weeks after implantation , 6 pieces of acellular dermal matrix were harvested and the size of implanted acellular dermal matrix were measured , the sections were used for he staining and observed under light microscope . the result were as folio wing : 1 - 2 weeks after implantation , the acellular dermal matrix began to adhere to the tissue around and turned red gradually ; 3 - 4weeks after implantation , the acellular dermal matrix adhered closely to the tissue around and could be recognized easily , 1 - 3 weeks after implantation , the size of implanted acellular dermal matrix had no statistical difference ( p > 0 . 05 ) . 4 weeks after implantation implanted acellular dermal matrix contracted ( p < 0 . 05 ) . under light microscope , l - 2weeks after implantation , the fibroblast cells infiltrated the acellular dermal matrix and a small amount endothelial cells of vessel and lympho - histiocytic cells infiltrated the acellular dermal matrix . 3 - 4 weeks after implantation , infiltrating blood vessels were evident . so we think that the acellular dermal matrix had low immunological reactions and could induce the infiltration of fibroblast macrophage cell and the endothelial cells of vessel 结果如下：皮下包埋卜周者，无细胞真皮基质渐与周围组织粘附，颜色由苍白转红；皮下包埋3周者，无细胞真皮基质与周围组织紧密枯附，盾晰叶辩；术后卜周，包埋的基质面积变化较包埋前无统计学差异o川0引，术后4周包埋的无细胞真皮基质面积较包埋前缩小j刃刀5 ） 。光镜下术后卜周，宿主的淋巳组织细胞、成纤维细胞浸入生长，釉附在胶原纤维上，少量血管内皮细胞浸入基质；术后34周，无细胞真皮基质内较多的血管形成，故可认为无细胞真皮基质免疫原性低，能诱导宿主的成纤维细胞、巨噬细胞浸入生长，为一种新型的真皮替代物。第四部分无细胞真皮基质与自体断层皮片复合移棺的研究， sd大鼠10只，在其背部卜方造成全厚皮肤缺损的创面
These studies support the hypothesis that ih might arise from invading angioblasts or placental cells and these epcs excessively secrete vascular growth factors , resulting in an increasing favorable local environment for endothelial proliferation , and contribute to aberrant endothelial growth in ih 认为可能的发病机制是调控细胞增殖及分化的基因区发生突变的内皮祖细胞过度分泌血管形成因子，造成局部微环境血管形成抑制的失衡，内皮细胞迅速增殖而形成婴幼儿血管瘤。
Endothelial cells were continuously cultured for 36 h after treating with angiostatin , endostatin and both of them , respectively . through transmission electron - microscope , we found all of them could induce apoptosis in endothelial cells . the effect of synergy between angiostatin and endostatin was stronger than either of angiostain or endostatin 本实验还探讨了人血管抑素可能的作用机理和人血管抑素、人内皮抑素以及两者的协同作用对体外培养的内皮细胞的增殖和对体内鸡胚新生血管形成的影响，并将三者的作用效果进行了比较。
