Jejunal biopsy through enteroscopic examination revealed atrophic villi and dense infiltration in lamina propria by lymphocytes , with extension beyond the layer of muscularis mucosa 我们报告一例具典型临床症状的31岁男性患者，其空肠切片检查看到黏膜固有层中有致密的淋巴浆细胞浸润，浸润程度已穿越黏膜肌肉层。
The histologic lesions were characterized by the remarkable atrophy of intestinal villi , basal vacuolation of enterocytes , increment of the crypt and the villus - to - crypt ratio had significantly decrease . compared with that of noninoculated control chicks . besides . intestinal villi become thin and flat . or cubic , also accompanied with necrosis . many villous enterocytes were detached from the lamina propria and the lamina propria contained a diffuse infiltrate of lymphocytes , plasma cells , macrophages . the characteristic ultrastructural changes observed by electronmicroscope were swelled mitochondria and dilated endo - plasticreticulum . ribosome on the surface of endo - plasticreticulum fall off and the number of ribosome within the cell decrease 动物回归试验中接种两周龄spf鸡， 24h后陆续发病，表现为持续性水样腹泻；剖检可见病鸡脱水、小肠内有大量的液体和气泡、肠粘膜变薄；组织学变化为肠绒毛上皮坏死、脱落，绒毛平均长度减少而隐窝深度增加，固有层中淋巴细胞浸润。其临床症状及病理组织学变化与自然发病相同。
