In this review , the developments of application of conventional high performance liquid chromatography , capillary methods , ultra performance liquid chromatography are described 本文评述了传统高效液相色谱技术、毛细管技术和超高效液相色谱等技术在代谢组学的应用。
In this paper , the definition and objective of metabolomics are provided , and the current application of metabolomic research in malignant tumors ( diagnosis and therapy ) are summarized 本文对代谢组学的概念、代谢组学研究的目的和领域以及代谢组学在恶性肿瘤研究中的应用方面进行了综述。
Conclusion the efficiency for finding of leading compounds could be improved if the isolation is based on metabonomics under the guidence of the new method of botanical mixture determination by 1h - nmr 结论基于植物代谢组学混合物氢谱测定指导下的分离是一种高效发现先导化合物的新方法。
Pr can be used not only to identify the differences of the pathological from the normal , but also to find which bio - fingerprints result in such differences , thus supplying valuable information for diagnosis 模式识别与生物核磁共振波谱的结合，已经发展成为代谢组学研究的关键技术，甚至被称为基于核磁共振的代谢组学。
1 fu y ， huang y ， huang px ， et al . research tendency of thrombolysis of acute ischemic cerebrovascular disease using traditional chinese medicine and metabonomic study . liaoning zhong yi za zhi . 2006 ； 33 （ 6 ） ： 662 ? 664 . chinese 付于，黄燕，黄培新，等。急性缺血性脑血管病的中药溶栓治疗与代谢组学的研究趋势。辽宁中医杂志。 2006 ； 33 （ 6 ） ： 662 ? 664
Mindful of the stumbles of other biotech companies , krotzky adds , metanomics has worked quietly for four years , completing internal proof - of - concept tests before making any public scientific claims 柯洛斯基时时以其他生技公司的悲惨命运为警惕，他补充说明，代谢组学公司四年来始终默默耕耘，完成了内部的测试、证实理论正确后，才对外公开他们的科技成果。
Recently , with the development of the metagenomics , proteomics , metabolomics etc . , the industrial microbial technology is under the way of innovation , and is exploiting the new field , such as the electronic technology and nano - micro technology 摘要近年来，随着宏基因组学、蛋白质组学和代谢组学等技术的发展，工业微生物技术在资源、医药和手性合成等领域已经成为热点技术，并开拓了电子和纳米技术等新的应用领域。
The main study for postdoctoral researcher is , who should has the ability in research of proteomics and metabolomics , to sieve out the disfuctional forecasted indexes of renal inadequacy in the pre - operation stage of liver transplantation for the prophylaxis and treatment of arf 招收博士后1名，拟在现有工作基础之上，采用蛋白质组学和代谢组学等研究手段，开展肝移植围术期肝、肾功能损坏预警指标的筛选和防治研究方面的工作。
On the one hand , the theoretics of drug discovery become more comprehensive and more profound as the development of numerous new disciplines such as genomics , proteomics , transcriptomics , metabonomics , bioinformatics and system biology ; on the other hand , the pathways for new drug discovery are broadened by the continuous improvement of technological platforms including computer - aided drug design , high throughput screening , high content screening , biochip , transgenic and rnai technology 一方面，基因组学、蛋白质组学、转录组学、代谢组学、生物信息学、系统生物学等新兴学科的崛起与发展，为药物发现提供更为广泛而深刻的理论基础；另一方面，计算机辅助药物设计、高通量筛选、高内涵筛选、生物芯片、转基因和rna干扰等高新技术的发展和完善，为药物发现提供了新的技术手段和有力工具，极大地拓宽了药物发现的途径。
The following research areas will be involved in the project : ( 1 ) mechanism of hereditic factors and its function in chinese type 2 diabetes ; ( 2 ) metabolomics on the cell stress and its nutrition intervention in the type 2 diabetes ; ( 3 ) mechanisms of metabolic nuclear receptors in the process of insulin resistance and type 2 diabetes onset ; ( 4 ) roles of signal transduction molecules , lipid metabolic disorder to insulin resistance ; ( 5 ) type 2 diabetes development and role of pathological changes of blood vessels ; ( 6 ) abnormal insulin secretion , apoptosis and type 2 diabetes ; ( 7 ) function of molecular network of type 2 diabetes progression 本项目拟开展以下研究工作： （ 1 ）中国人2型糖尿病发生过程中遗传因素的发现及其作用机制； （ 2 ）细胞应激在中国人2型糖尿病发生过程中的作用机制及其营养干预的代谢组学； （ 3 ）代谢性核受体在胰岛素抵抗和2型糖尿病发病中的作用机制； （ 4 ）细胞信号转导分子、脂代谢紊乱与胰岛素抵抗的关系； （ 5 ） 2型糖尿病发展过程与血管病变； （ 6 ）胰岛素分泌异常、细胞凋亡与2型糖尿病； （ 7 ） 2型糖尿病发生过程中的分子网络与作用机制。
