As demonstrated in large clinical trials of 2 to 4 years ' duration , these medications significantly increase weight loss compared with placebo ; weight loss with these drugs reaches a nadir between 20 and 28 weeks ; weight loss , averaged 8 % - 10 % , with the placebo contributing 4 % - 6 % of that 为期2 - 4年的大规模临床实验显示，这些药物与安慰剂相比可明显使体重减轻；这些药物引起的体重减轻在20 - 28周达到最低；可使体重平均降低8 - 10 ，而安慰剂仅为4 - 6 。
In the , sandwichman , distributor of throwaways , nocturnal vagrant , insinuating sycophant , maimed sailor , blind stripling , superannuated bailiff s man , marfeast , lickplate , spoilsport , pickthank , eccentric public laughingstock seated on bench of public park under discarded perforated umbrella . destitution : the inmate of old man s house royal hospital , kilmainham , the inmate of simpson s hospital for reduced but respectable men permanently disabled by gout or want of sight . nadir of misery : the aged impotent disfranchised ratesupported moribund lunatic pauper 行乞方面：欺诈成性的破产者，对每一英磅的欠款只有一先令四便士的微乎其微的偿还能力者，广告人，撒传单的，夜间的流浪汉，巴结求宠的谄媚者，缺胳膊短腿的水手，双目失明的青年，为法警跑腿的老朽318 ，宴会乞丐，舔盘子的，专扫人兴的，马屁精，撑着一把捡来的净是窟窿的伞，坐在公园的长凳上，成为公众笑料的怪人。
