10 o shea j j , gadina m , schreiber r d . cytokine signaling in 2002 : new surprises in the jak stat pathway . cell , 2002 , 109 suppl : s121 - s131 . 11 boehm u , klamp t , groot m , howard j c . cellular responses to interferon - gamma 鲁棒性的结论表明jak - stat信号通路的“信号时间” signal time和“信号持续时间” signal duration对外界扰动比较鲁棒，而“信号幅度” signal amplitude则对外界扰动比较敏感。
The effects of the variations of the initial signal proteins concentrations on the output of this system are also studied . the study demonstrates that the jak - stat signaling pathway is robust with respect to its signal time and signal duration , but sensitive with respect to its signal amplitude 我们主要考察了细胞信号转导过程中三个重要的特征量的变化，即“信号时间” signal time “信号持续时间” signal duration以及信号幅度signal amplitude 。
Jak2 is one of the janus kinase family . it participates in the jak - stat signal transduction and plays roles in signal transduction of many cytokins and growth factors such as growth hormone , il and gm - csf . it plays essential roles in cellular functions , i . e . cell proliferation and differentiation Jak2是janus激酶家族中的一员，参与jak - stat信号通路，介导诸如生长激素、白细胞介素、 gm - csf等细胞因子和生长因子的信号传导，在细胞的增殖、分化等活动中起重要作用。
By nuclear transferee transfered the nih 3t3 cell to enucleated gv and mii oocyte . the immunofluorescence results showed that jak . 2 was not transfered to somatoblast nuclear whether the recombined oocyte occured gvbd or not . when transfered somatoblast nuclear to enucleated and integrated m ii oocyte , the immunofluorescence results showed that jak2 only existed in the nuclear of integrated m ii oocyte but not the somatoblast nuclear . the nuclear transfer implied that the mature and immature oocyte cytoplasm could not transfer the jak . 2 protein to donor nuclear 通过核移植，将nih3t3体细胞核移入去核gv期和m期的卵母细胞中。荧光检测发现，体细胞核与去核gv期卵母细胞质构成的重组卵无论是否发生gvbd ，核内均没有jak2的出现。在去核和未去核的m期卵母细胞中移入体细胞核， jak2仅存在于未去核m期卵母细胞的核内，并不转移到体细胞核内。
