Studies of genes related to heart development in drosophila contribute to reveal the mechanisms of human heart development and the congenital heart diseases . to clone and identify new genes that control the heart development , by a way of chemical mutagen , ems , we have established 1 , 200 balanced - lethal lines on chromosome 2 and 3 . with the screening the 330 stocks with immunochemical method using heart - specific antibody , mab . no . 3 , we detected 60 lethal lines showing heart mutant phynotype 为了克隆和鉴定控制心脏发育的新基因，本研究利用化学诱变剂甲磺酸乙酯大规模地诱变果蝇，并且建立了1200个第二和第三染色体的平衡致死系，利用心脏组织特异抗体mab . no . 3对其中330个品系进行免疫化学方法筛选，观察到有60个致死系表现出心脏突变表型， 20个品系的心脏突变表型有待进一步证实。
Rab proteins are a family of small molecular weight gtpase of ras superfmaily with characteristic molecular weight about 22 - 25 kd . rab gtpases are expressed in almost all eukaryotic cells , ranging from yeast to drosophila and to human . they are ubiquitously or tissue - specifically expressed and function in all of cellular aspects Rab蛋白是属于ras蛋白超家族的小g蛋白( smallg - proteinorsmallgtpase ) ，分子量大多在22 - 25kda之间，表达于从酵母、果蝇、小鼠到人类等各种真核生物中，发挥着各种各样的功能；其在酵母中称为ypt sec4p在高等真核生物中称为rab 。
Many organisms produce enzymes , termed photolyases , that specifically bind to these damage products and split the via a uv - a / blue light - dependent mechanism ( photoreactivation ) , thereby reversing the damage . these two photolyase are specific for either cpds ( cpd photolyase ) or 6 - 4 products ( 6 - 4 photolyase ) . a gene that expresses a protein with 6 - 4 photolyase activity in vitro , was recently cloned from high organisms ( arabidopsis thaliam , drosophila melanogaster , danio rerio , xenopus laevis and homo sapiens ) 目前已从高等生物拟南芥、鲐类、果蝇、人类和非洲爪蟾蜍属中克隆到有( 6 - 4 )光裂合酶活性的基因，本研究从盐生杜氏藻dunaliellasalina中克隆到( 6 - 4 )光裂合酶的基因，并将该基因在大肠杆菌中得以表达，这是首次在藻类中克隆到( 6 - 4 )光裂合酶基因，对光裂合酶的研究具有重要意义。
Additional specific topics include : constructing and modeling of genetic networks , lambda phage as a genetic switch , synthetic genetic switches , circadian rhythms , reaction diffusion equations , local activation and global inhibition models , center finding networks , general pattern formation models , modeling cell - cell communication , quorum sensing , and finally , models for drosophila development 外加的特定题目尚有：建构基因网络的模型、以嗜菌体作为基因开关、合成基因开关、日夜节律、反应扩散方程式、局部活化和整体抑制模型、中心寻找网络、整体型式生成模型、细胞间讯息互换的建模、数量感应，最后也将探讨果蝇的发育模型。
