Kinetic study shows that nadp + is the only valid coenzyme and that one substrate have no effect on the the other substrates " bind with the enzyme . products are competitive inhibitors , nadp + / nadph and 6 - phosphogluconate / ribulose - 5 - phosphate pairs are competitive whatever the concentration of the other substrates but noncompetitive versus the other substrates . therefore the kinetic mechanism of the 6 - phosphogluconate dehydrogenase is haldance - laidler - socquet random mechanism 两种底物与酶的结合互不影响，而在产物抑制效果上， 5一磷酸核酮糖只竞争性抑制6一磷酸葡萄糖酸， nadph只竞争性抑制nadp + ，所以该酶催化机理是haidance一laidier一socquet随机机理。
