Conclusions electron microscopic obser vations show that the alveolar epithelial cells , endothelial cells and basement membrane are all injured , interstitial macrophages hyperpplasia , mast cells infiltration and degranulation , electron - dense deposits at alveolar wall are present 结论电镜观察可见特发性肺纤维化时肺泡上皮细胞、血管内皮细胞及基底膜均有损伤，并可见间质巨噬细胞增生，肥大细胞浸润及脱颗粒，肺泡壁电子致密物沉积。
Results the major morphologic changes were as follows : histologically , alveolar inflammation and interstitial fibrosis were observed . electron microscopic findings were : 1 . alveolar type i cells were degenerated 、 broken - down and desquamated , endothelial cells were swelled , with inter cellular tight junction shortened , alveolar type ii cells hyperplastic , basement membrane thinned and deformed ; 2 . alveolar macrophages and interstitial macrophages were hyperplastic ; 3 . mast cells were infiltrated and degranulated ; 4 . electron - dense deposits were present at alveolar wall ; 5 . myofibroblasts 、 fibroblasts 、 collagen and basement membrane like material were hyperplastic 电镜观察可见： ( 1 ) i型肺泡上皮细胞变性、崩解和脱落，内皮细胞肿胀，细胞间紧密连接短小， ii型肺泡上皮细胞增生，基底膜变薄和破坏； ( 2 )肺泡巨噬细胞、间质巨噬细胞增多； ( 3 )肥大细胞浸润并见脱颗粒现象； ( 4 )肺泡壁电子致密物沉积； ( 5 )肌纤维母细胞、纤维母细胞、胶原原纤维及基底膜样物质增生。
Results there were 3 pathological characteristics in alhe : massive hyperplasia of capillaries in the dermis ; the endothelial cells proliferated and swelled , projecting into vascular cavity like tombstones ; mixed infiltration of lymphocytes and eosinocytes in the vessels 结果伴嗜酸性粒细胞增多性血管淋巴样增生在病理学上有其特征，形态学上的改变主要表现在以下3个方面：真皮内大量毛细血管增生；血管内皮细胞增生肿大，似“墓碑”状突入血管腔；病变处有淋巴细胞、嗜酸性粒细胞混合浸润。
