In an open - label , randomized study conducted in 40 u . s . and canadian centers , the team surveyed treatment satisfaction , quality of life , and adherence barriers at weeks - 4 , - 1 , 6 , 12 , 20 , and 24 in adolescents and adults with type 1 diabetes 在由40个美国和加拿大中心进行的一项公开随机研究中，这个组织调查了1型糖尿病青少年和成年患者在胰岛素治疗前4周、前1周和胰岛素治疗后6 、 12 、 20 、 24周的治疗满意度、生活质量和依从性。
Current drug therapies are not practical for global control due to the high cost , problems with patients " compliance and the emergence antibiotic resistant strains . therefore , vaccination against h . pylori has been considered to control h . pylori infection 药物治疗hp存在较大的局限性(药物毒副作用、费用昂贵、患者依从性差及耐药菌株不断增多等) ，而疫苗接种可使人群获得持久、有效的免疫力，是从人群中消除hp的有效措施之一。
Methods by defining defaulting as a failure event and time from treatment starting to defaulting as survival time , we applied survival analysis technique with a real data to estimate a so called adherent rate and a median adherent time for evaluation of treatment adherence for patients with tuberculosis 方法将退出疗程作为所关心的结局事件，将从登记治疗开始到退出疗程的时间作为坚持治疗时间，利用生存分析统计技术估计坚持治疗率和中位坚持治疗时间以评价结核病患者的治疗依从性。
They firstly used compliance as an explanatory variable in the clinical trials . however , compliance often ca n ' t be measured exactly . following the simple model put forward by them , we develop a new model that allow compliance with random errors and separate the effectiveness of treatment from that of the compliance 然而，依从性往往很难被精确测得，因此基于他们提出的简单模型，我们提出一个新的模型允许其中的依从性变量带有量测误差，并把治疗( treatment )的效应和依从的效应分离出来，从而得到一个更符合实际的对照临床试验数据的ev模型。
