However , for the side effects of such medicines , food protein - derived aceis , known as angiotensin converting enzyme inhibitory peptides ( aceips ) , which are considered as safer and more natural , have received great interests in the therapy of hypertension 但是使用药物治疗都有一定的副作用，所以，寻找安全的、天然的、食物来源的acei物质来治疗高血压引起了广大科学家们极大的关注。
However , by far , all the milk - derived antihypertensive peptides ( also known as angiotensin converting enzyme inhibitory peptides , aceips ) are produced by the proteinase hydrolysis of milk proteins , no report is available on aceips expressed by dna recombinant technology 然而，到目前为止，所有的乳源抗高血压小肽都是通过蛋白酶对乳蛋白质的水解获得的，还没有通过基因工程技术来表达抗高血压小肽的研究报道。
So far , six kinds of medicines are authorised to be applied to the treatment of hypertension by the world health organization ( who ) , including diuretics , - receptor blocking agent , - receptor blocking agent , angiotensin receptor antagon , calcium channal blocking agent and angiotensin converting enzyme inhibitors ( aceis ) 目前，世界卫生组织( who )批准用于治疗高血压病的一线药物主要有利尿剂、受体阻断剂、血管紧张素转换酶抑制剂( acei ) 、钙通道阻滞剂( caa ) 、受体阻断剂、血管紧张素( ang )受体拮抗剂等六大类。
In the first part of the present work , the expression changes of angiotensinogen ( agt ) and angiotensin - converting enzyme ( ace ) as well as its time course characteristics were investigated by rt - pcr , in situ hybridization and western blotting . we also prepared the polyclonal antiserum against agt for the following work 故本工作应用rt - pcr和原位杂交、 western印迹分析等方法对模拟失重大鼠不同部位动脉血管血管紧张素原( angiotensinogen ， agt )及血管紧张素转化酶( angiotensin - convertingenzyme ， ace )基因表达变化的时程特征进行了观察，并为后续工作制备了抗agt多克隆抗血清。
Renin - angiotensin system ( ras ) plays an important role in the regulation of peripheric blood pressure , where angiotensin converting enzyme ( ace ) is considered to be the core of the system . ace plays a key role in increasing the blood pressure by catalyzing the formation of the potent vasopressor angiotensin ii ( ang ii ) from angiotensin i ( ang i ) 在该系统中， ace酶是血压调节过程中一个关键的酶，它可以将无活性的血管紧张素( ang )水解生成具有血管收缩作用的血管紧张素( ang ) ，从而导致血管收缩，机体的血压升高。
