Characteristics of changes of histology and biomechanics in the repair of radial bone defects of rabbits with true bone ceramices combined with type collagen and bone morphogenetic protein 型胶原复合骨形态发生蛋白修复兔桡骨缺损过程中的组织学与生物力学变化特征
4 wang ea ， rosen vd ， alessandro js ， et al . recombinant human bone morphogenetic protein induces bone formation . proc natl acad sci usa ， 1990 ， 87 : 2220 5戴毅敏，陈新梅，毛天球，等.基因重组人骨形态蛋白- 2和牛骨形态蛋白异位诱导成骨的比较.实用口腔医学杂志， 2002 ， 18 （ 4 ） : 326 - 328
Clr is a complement serine protease , composed of two cub ( clr / cls , an embryonic sea urchin protein uegf , and bone morphogenetic protein i ) domains , one egf domain and one serine protease domain 补体组分c1r含有两个cub结构域，一个egf结构域和一个丝氨酸蛋白酶结构域，是一种丝氨酸蛋白酶原。
Here we report that bone morphogenetic proteins ( bmps ) , amongst which bmp4 elicits the strongest effect , trigger a significant reduction in the stem - like , tumour - initiating precursors of human glioblastomas ( gbms ) 本研究我们报告骨形成蛋白4最大程度的降低人类恶性胶质瘤干细胞样致瘤前体细胞的致瘤作用。
Hydrophobicity analysis predicted a 36 - residue hydrophobic signal peptide for secretion in the n - terminus , and no transmembrane region was present , suggesting it might be a type of secretory protein . some generic and atipical n - glycosylation sites were present in clsp , suggesting that the protein might represent a glycoprotein . the clsp protein contained one cub ( clr / cls , an embryonic sea urchin protein uegf , and bone morphogenetic protein i ) domain from 39th to 164th ammo acids , which is known to be involved in protein - protein or protein - substrate interaction , and a trypsin - like serine protease domain positioned from 244th to 483rd amino acids Clsp分子具有补体样丝氨酸蛋白酶的多种结构特征，包括36个氨基酸组成的疏水信号肤，一个cub ( clr / cls ， anembryonicseaurehinproteinuegf ， andbonemorphogeneticproteinl )结构域和一个胰酶样丝氨酸蛋白酶结构域( t汀psin一likeserineproteasedomain )和几个保守的糖基化位点等，没有发现有跨膜区的存在。
Human bone morphogenetic protein 3 is a member of tgf - b superfamily . lt can induce the differentiation of cartilage and bone tissue in mesenchymal cell . and is important to bone self - repairment and bone development during embryo morphogenesis . in addition , some other biological activities of hbmp - 3 have also been found . such as inducing development of embryo and stimulating differentiation of neural and blood cells . therefore , there is a great prospect in the use of hbmp - 3 . there is trace content of hbmp - 3 in human body . it has been expressed in the expression system of eukaryotes and prokaryotes respectively , but its application is restricted because of defects in the process and modification after translation in prokaryotic cells and higher costs and lower yields existed in eukaryotic expression system 人骨形成蛋白3 ( hbmp - 3 )属于tgf -超家族的一员，可以诱导间充质细胞分化为软骨和骨，在胚胎时期骨骼发育和骨再生修复中起着重要的作用，而且对胚胎发育过程中中胚层的诱导和分化、造血组织的发育以及神经系统的发育和修复等都起着重要作用，因而hbmp - 3有广阔的市场前景。它在人体内含量极微，尽管研究人员已经在原核细胞和真核细胞表达系统中分别进行了表达，但是由于原核表达系统缺乏翻译后的加工修饰，真核表达系统存在成本高、产量低等特点，限制了其在临床上的应用。
