However , recent data suggest muscarinic acetylcholine receptor machr autoantibody plays an important role in the disease pathogenesis . we have demonstrated different machr autoantibodies in different ss patients 最近研究显示蕈毒乙醯胆硷受体之自体抗体，在修格连症候群致病机转中，扮演重要角色。
The toxin can reversible block the neuromuscular transmission in an isolated mouse phrenic nerve - diaphragm preparation and also is a neurotoxin ( n - type ca2 + channels inhibitor ) which binds to the postsynaptic nicotinic acetylcholine receptor ( nachr ) 溶液构象研究表明，它采取自然界中其它蛋白质多肽普遍采用的一种紧凑、致密的抑制剂胱氨酸结模体( ick ) 。
Acquired mg is an autoimmune disease in which the body immune system mistakenly attacks and destroys special proteins ( acetylcholine receptors ) located on the muscle surface where the nerve attaches to the muscle 犬重肌无力症属于一种自身免疫性疾病,疾病的发病机理为狗体内免疫系统攻击并毁灭相关的特殊蛋白,这类作为乙酰胆碱受体的蛋白质主要位于肌肉表面与神经结合处
Due to the toxin ' s pharmacological effect of inhibiting acetylcholine release from presynaptic neuromuscular junctions , botulinum a toxin has been used for the treatment of spastic urethral sphincter as well as detrusor overactivity associated with both neurogenic and non - neurogenic etiologies 基于它在药理学上可以抑制神经肌肉接合前之乙醯胆硷之释放，肉毒杆菌毒素也被应用于神经性因或非神经性因之尿道外括约肌痉挛及逼尿肌活性过强。
Sleep / waking cycle is a complex network modulation and many factors such as interleukin - 1 ( il - 1 ) , tumor necrosis factor ( tnf ) , growth hormone releasing hormone ( ghrh ) , vasoactive intestina polypeptide ( vip ) and many conventional neurotransmitters such as serotonin ( 5 - ht ) , acetylcholine ( ach ) , norepinephrine ( ne ) , dopamine ( da ) and gamma - aminobutyric acid ( gaba ) were involved in it . recent evidence has shown that no synthesized in neurons in several areas of the brain can induce the release of neurotransmitters . in the rat central nervous system , the anatomical distribution of nos - containing neurons is now well established , and it was reported that nos is co - localized with neurotransmitters well known for their involvement in sleep mechanisms , i . e . 5 - ht , ach , da and gaba 郑州大学2003届硕士毕业论文gaba受体激动剂消除no合成酶抑制剂对大鼠睡/醒周期的影响睡/醒周期的形成是一个复杂的网络调控的结果，体内许多因子都参与了这一调控网络，这些因子如白介素一1 ( il一1 ) 、肿瘤坏死因子( tnf ) 、生长激素释放激素( ghrh ) 、血管活性肠肤( vip )以及经典的神经递质如5一轻色氨( 5一ht ) 、乙酞胆碱( ach ) 、去甲肾上腺素( ne ) 、多巴胺( da )和卜氨基丁酸( gaba )等，它们在睡眠的发生和调节中也发挥着重要作用。
The experimental results showed that tongbian fang had the antagonistic effect on the inhibition of small intestine propulsion induced by adrenaline , atropine and morphine hydrochloride in mice , increased the water volume in intestinal cavities , excited the spontaneous movement of rabbit duodenum in vitro , antagonized the adrenaline - induced inhibition of duodenum movement in vitro and the acetylcholine - induced contraction of ileum in vitro 研究结果表明，通便方能拮抗肾上腺素、阿托品、盐酸吗啡引起小鼠小肠推进的抑制；能显著增加小鼠肠腔水分；对家兔离体十二指肠自发运动有兴奋作用，能拮抗肾上腺素引起的离体十二指肠运动抑制和乙酰胆碱引起离体回肠的强直性收缩。
