According to the new report entitled treatment algorithms in rheumatoid arthritis , this limited penetration is due primarily to payer restrictions on reimbursement ; patients must often fail therapy on methotrexate before the high cost of biologics will be reimbursed by health care plans 根据这一名为类风湿性关节炎的治疗方法的报告，生物制剂受到限制主要是因为支付人偿付受限；通常病人必须在接受氨甲蝶呤治疗失败后，费用很高的生物制剂才被医疗保险计划偿付。
Result the reasons of operational failure were found to be the use of unreasonable regimens and existance of drug resitant strains ; inappropriate operational indication , approach and treatment during operation ; lesions involving several vertebras , skipping destruction and complicating with other kinds of extrapulmonary tuberculosis 结果治疗失败的主要原因为：化疗不合理及耐药菌株的产生；手术时机、术式选择及术中处理不当；多椎体病变、跳跃型病变及合并其他肺外结核。
