However , trials of il1ra for osteoarthritis have had limited success , primarily because the drug tends to break down quickly , according to the researchers 然而il - 1受体拮抗剂治疗骨关节炎的临床实验仅取得有限成功，研究人员认为主要是因为药物代谢太快。
Terri j , zemin c , sherif y , et al . role of angiotensin and bradykinin in experimental diabetic nephropathy . funcational and structure studies . diabetes , 1997 , 46 : 1612 文晖,林善锬.血管紧张素受体拮抗剂氯沙坦对糖尿病大鼠肾脏的保护作用.中华内科杂志, 1999 , 38 ： 157
Results two patients with persistent hypertension needed calcium ion antagonist combined with acei , the others got a satisfied blood pressure level with cardura 结果除2例持续性高血压患者需联合钙离子拮抗剂和acei药物降压外，其余患者采用可多华降压均取得令人满意的结果。
During hs at 44 , the cam antagonists w7 and cpz als o inhibited dna - binding activity of the hsf in a concentration - dependent manner , but not by w5 , an inactive structural analogue of w7 Cam拮抗剂w7和cpz都可抑制热激诱导的hsf的dna结合活性，而w7的类似物w5无此抑制作用。
Wether leukotrien - antagonists , which have recently been introduced in the management of asthma , will widen the panel of traditional anti - allergic agents ; will be shown in the near future 最近上市用于治疗哮喘的白三烯拮抗剂，是否丰富传统抗过敏药的宝库，这在不远的将来会显示出来。
Then we know that especially thiazide diuretics and calcium antagonists are very well proven in the elderly women , for example , systolic hypertension , we have several trials 我们知道噻嗪类利尿剂和钙离子拮抗剂在老年女性患者中的应用得到了证实，比如收缩期血压，我们有若干个临床试验。
Nmda receptors are crucial in acute glutamate neurotoxicity , nmda - antagonists could reduce neuronal death in animal models of ischamic or hypoglycemic brain injury Nmda受体在介导急性谷氨酸兴奋性毒性中起了关键性作用， nmda受体的拮抗剂的使用能降低缺血性或低糖脑损伤动物模型中的神经元死亡。
Drazen j . effect and safety of leukotriene d4 - receptor antag2 onist ici204 , 219 on airway inflammatory mediators in atopic asthma [ j ] . am j respir crit care med , 1998 , 157 : s233 许文兵,朱元珏,郭盛祥,等.白三烯受体拮抗剂扎鲁司特治疗中、轻度哮喘的疗效和安全性评价[ j ] .中华结核和呼吸杂志, 2000 , 23 ( 3 ) : 164
Zannad f , alla f , dousset b , et al . limitation of excessive extracellular matric turn over may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure . circulation , 2000 , 102 : 2700 程远植.醛固酮拮抗剂螺内酯在慢性心衰的治疗作用和应用进展.中华心血管杂志, 2003 , 31 : 69 - 71
In the muscle strips sensitized with histamine , the dopamine - induced contraction was decreased by the antagonist to 2 - adrenoceptors and increased by the antagonist to 1 - adrenoceptors 在这些被组织胺敏感化的肌肉中，多巴胺所引致的收缩可因-肾上腺素接受器的拮抗剂存在而减弱，或因-肾上腺素接受器的拮抗剂存在而加强。
