Molecular imprinting technique ( mit ) is a new applied widely technique in recent years which combine the advantages of the subjects of macromolecular synthesis , molecular design , molecular recognition and bionic bioengineering 摘要分子印迹技术是近年来集高分子合成、分子设计、分子识别、仿生生物工程等众多学科优势发展起来的一种应用广泛的新型技术。
Molecular recognition is utilized to describe the molecular binding process in a specific manner . it ' s well known that the antibody / antigen , receptoraigand and enzyme / substrate are the three molecular recognition models in animate bodies 分子识别是分子间专一性的结合过程，抗体与抗原、受体与配体、酶与底物是人们所熟悉的生物体内的分子识别的三个模型。
Supramolecular action is a kind of molecular interaction with molecular recognition ability . it includes van der waals and electrostatic interactions , hydrogen - bonding , - bonding and hydrophobic interaction , which are accompanied by spacial effect 超分子作用是一种具有分子识别能力的分子间相互作用,是空间效应影响下的范德华力、静电引力、氢键力、相互作用与疏水相互作用等。
Collection of supramolecules chemistry theory and liquid crystal science results in a novel science field : supramolecules liquid crystals , which is aim to synthesize more and more liquid crystalline material by molecules recognization and self - assembly and acknowledge more about them 这一领域的目标是通过分子识别和自组装，在更广泛的空间去合成新的液晶材料，了解液晶科学领域更多未知的东西。
Mips are suited as bio - mimetic materials due to their long - term stability , durability to extreme physical and chemical conditions . therefore , molecular imprinting paves a new way for sensing technique overcoming the disadvantages of the biological recognition methods 与天然的生物分子识别系统如单克隆抗体或受体相比， mip具有很高的选择性和稳定性，因此适合于用作模拟生物传感器的识别元件。
Analytical methods using biological materials such as enzymes , receptors and antibodies suffer from a lot of disadvantages , e . g . complex and time - consuming procedures , poor stability and reproducibility although showing a high selectivity with these molecular recognition agents 生物物质如酶、受体、抗体等作为分子识别元件具有很高的选择性能，但是这些物质往往不易长期保存，且操作稳定性不高。
The love wave device with the substrate of st - cut quartz and the guiding layer of si02 was used as the saw biosensor . dna sensor employing synthetic seb dna probe as a molecular recognizing component was utilized to detect seb by measuring seb dna in samples 该传感器采用以st一切割的石英晶片为基体，以510 :为波传导层的乐甫波( lovewaves )装置，利用具有分子识别功能的dna合成探针来实现对样品中sebdna的检测。
Recently , there has been rapid development in the research and application of biosensor , which can detect analytes selectively using the specific reaction of bioactive materials such as the enzyme - substrate , enzyme - coenzyme , antigen - antibody , incretion - acceptor and so on 近年来,生物传感器的研究和应用发展迅猛,它利用生物活性物质的亲和性,如酶-底物、酶-辅基、抗原-抗体、激素-受体等的分子识别功能,可以有选择地检测待测物。
Molecular imprinting is a rapidly expanding technique to create molecularly imprinted polymers ( mips ) with high selectivity . this technique is a powerful method for preparing the tailor - made binding sites based on the molecular structure and functional group of the analyte 通过分子印记技术可以获得稳定的合成聚合物? ?分子印记聚合物（ mip ） ，它的识别部位可根据待测分子的结构和官能团来进行“量身”定做，因此具有选择分子识别的性质。
The latter plays a very important role in the study of the mechanism and dynamics of the recognition . it includes the molecular modeling , confirming the binding sites , the calculation of interactions between receptor and ligand , the docking research of the complex , the calculation of dynamic and thermodynamic properties etc . many theoretical calculation methods are involved , such as quantum chemistry , molecular mechanisms , molecular dynamics , monte carlo method and free energy calculation and so on 其中计算机模拟方法是研究分子识别机制及其动态过程的重要途径，包括底物及受体分子模型的构建、底物及受体相互作用位点的确定、相互作用力的计算、底物及受体分子的对接及其动态过程的研究、体系热力学及动力学性质的计算等方面内容。
