In order to supply valuable information for industrial manufacture of ciprofloxacin , this paper gives a review on the synthetic process of ciprofloxacin such as raw materials , solvents , synthesis , methods , temperature and the ways for dealing with the product 本文针对环丙沙星生?中呱嗪缩合工艺如原料、溶剂、合成方法、反应温度及后继处理方法进行了概述， ?环丙沙星合成的工业化生?提供了宝贵信息。
Nineteen isolates among 89 isolates showed a lower resisance to nalidixic acid , ciprofloxacin , sarafloxacin , enrofloxacin , orbifloxacin and levofloxacin , and the remainder were susceptible . pcr was used for the amplification of intregron gene of all the salmonella isolates 89株分离菌株中，发现有19株对萘啶酸、环丙沙星、恩诺沙星、沙拉沙星、奥比沙星、左氟沙星表现出轻度的耐药性，其余菌株为敏感菌株。
Results antimicrobial resistant rates of pseudomonas aeruginosa increased gradually year by year , resistance to imipenem , ciprofloxacin and levofloxacin grew faster , which increased from 0 , 8 . 6 % and 20 . 0 % in 2002 to 9 . 5 % , 28 . 6 % and 41 . 0 % respectively in 2004 结果铜绿假单胞菌对多种常用抗菌药物的耐药率有逐年增高趋势，耐药率上升较快的抗菌药物有亚胺培南、环丙沙星、左氧氟沙星，分别由2002年的0 、 8 . 6 % 、 20 . 0 %增至2004年的9 . 5 % 、 28 . 6 % 、 41 . 0 % 。
As the first developer and manufacturer of norfloxacin eye drops , ciprofloxacin eye drops and artificial tears , liye pharmaceutical is determined to be a celebrated listed company with 3 years efforts relying on brand - new business idea , normative marketing management and high performance sales network 是第一家研制出诺复沙星滴眼液环丙沙星滴眼液及人工泪的厂家，将以全新的经营理念规范的销售管理和高效的营销网络为依托，用三年时间做成上市公司及知名企业。
Warning and precautions : ciprofloxacin should be used with caution in epileptics and patients with a history of cns disorders and only if the benefits of treatment are considerect outweigh the risk of possible cns side - effects . ciprofloxacin could result in an impairment of the patient ' s ability to drive or operate machinery , particularly in conjuncyion with alcohol 注意事项：盐酸环丙沙星慎用于癫痫病及有中枢神经紊乱史的病人且只有当治疗作用被认为超出其可能产生中枢神经副作用的危险时才可以使用，盐酸环丙沙星可能引起病人驾车和操纵机器的功能损伤，尤其是酒后。
