蛋白结合

• Cortactin , a novel member of filament actin binding protein family and the main substrate of non - receptor src protein kinase , plays an important role in the dynamic organization of cell cortex cytoskeleton
  皮层蛋白( cortactin )是一种微丝肌动蛋白结合蛋白，它与肌动蛋白纤丝的侧面相结合，并直接参与皮层细胞骨架的组建。
• The pharmacokinetic profile of lev closely approximates the ideal characteristics expected of an antiepileptic drug , with good bioavailability , linear and time - invariant kinetics , minimal protein binding , and least metabolism
  左乙拉西坦几乎具备了较好的抗癫痫药物的所有药动学特性：生物利用度高、线性曲线、低蛋白结合率、无肝酶诱导作用。
• But where glucose forms tight bonds with the long - lived protein collagen , the result is a constellation of changes , including thickened arteries , stiff joints , feeble muscles and failing organs - the hallmarks of a frail old age
  然而，人体中的萄葡糖一旦与生命期长的胶原蛋白结合就会产生一系列重大变化，诸如动脉变厚，关节僵硬，肌肉乏力，器官衰退等年迈体虚的特微。
• Bioorganic chemistry is a new discipline emerging from the interaction of biology and organic chemistry especially in the field to study the binding of a small molecule to the protein that results in a perturbation of function , either inhibition or activation
  生物有机化学是生物学和有机化学相互交叉发展起来的新领域，特别是小分子与蛋白结合后引起蛋白功能变化的研究如抑制作用和活化。
• It is known that many morbid conditions can be linked to changes in proteins , so it is important to enhance our knowledge of what proteins bind to each other , how they work together , and how processes are impacted by various disturbances
  我们已知很多疾病状态同蛋白质的改变相关，所以何种蛋白可以同其他蛋白结合、它们如何协同作用以及大量干扰如何对这些进程产生作用的知识就是我们迫切需要知道的。
• Recently , a great number of biochemical analyses and immunoctochemical experiments have proved that actin presents in nuclei and chromosomes in plants and animals , showing that actin is involved in the nuclear processes such as chromosome condensation , rna transcription and so on
  肌动蛋白主要存在于细胞质中，是细胞骨架微丝的重要组成成分，受多种肌动蛋白结合蛋白的调控，参与与细胞形态和结构相关的多种生理过程。
• In plants , actins are encoded by multi - gene families . there are many kinds of actin isoforms expressed in tissue - specificity and different phases during plant development for different functions . actin isoforms have complicated interactions with actin - binding proteins
  肌动蛋白异型体在植物体内的表达具有组织特异性，在植物生长发育的不同阶段具有不同的表达模式，从而发挥不同的功能，它们与众多肌动蛋白结合蛋白也具有不同的相互作用。
• Cascades are important in signaling pathways , there extracellular signals ( such as hormones or ions ) bind with receptors on the cell membrane , triggering changes in membrane proteins that activate proteins on the cytoplasmic side of the emmbrane , setting off a chain of reactions
  在信号传导通路上级联反应起着重要的作用，细胞外的信号（激素，离子等）和细胞膜上的受体结合，引起膜蛋白的变构，进而和细胞膜上靠近细胞质的蛋白结合，引发一系列的反应。
• Different rab gtpases interact with different effector proteins , but different rabs can also bind the same effector ( bifunction effector ) , e . g . rab4 and rab5 both can interact with rabaptin - 5 . one rab protein may associate with two or more effectors , suggesting the multifunctions of a rab protein
  不同的rab蛋白结合的效应蛋白不同但也可以结合同一种效应蛋白，即所谓的双功能效应蛋白( bifunctionaleffector ) ，如rab4和rab5都可以和效应蛋白rabaptin - 5结合。