Although it was shown that th could up - regulate the activity of 11 - hsd1 in primary cultured hepatocytes , whether the expression of 11 - hsd1 was also altered in hippocampus by th remained unknown . this paper was designed to observe the effect of th on 11 - hsd1 " s activity and expression in the newborn rat ' s hippocampus 但在新生50大鼠脑的晚期发育过程中，甲状腺激素是否通过调节脑内糖皮质激素的受体前代谢酶一， 1乃一hsoi的表达，从而参与糖皮质激素促进脑发育和成熟的作用，目前尚未见报道。
( 6 ) pdgf may initiate neuronal differentiation in nsc . nsc induced by pdgf , transcription and translation level of different thrs genes were up - regulated compared with the nsc induced by serum . the results made a great foundation for the further research of the important role of thrs during the cns development , and have much clinical significance on therapy of cretinism ^ subcretinism a Thr各亚型在不同分化细胞中表达不一致： （ 0l ；能诱导nsc向少突胶质细胞分化，并通过thr各亚型的时空表达来发挥其重要生理作用门印叩朴能引发vc向神经几分化，与10血清诱导分化相比能在转录与翻译水平上提高nsc分化后thr各亚型的表达本研究结果将为深入研究t在脑发育中的作用提供宝贵的实验依据，并对克汀病、亚克汀病以及ms脱髓鞘病等的临床治疗提供新途径，具有重要指导意义。
