The promise of these drugs is also connected to the fact that we have begun to understand that rennin may have effects independently on the formation of angiotensin ii to the traditional pathways 之所以说这种新药很有前景还有一部分原因是，我们已经开始懂得肾素对血管紧张素ii的形成有一定的作用，且这种作用不依赖于传统的作用途径。
However , the mechanisms of this differential adaptation are still not well understood . we hypothesized that local renin - angiotensin system ( l - ras ) might function as an local regulatory mechanism 这种分化性适应的调节机制目前尚不清楚，我们推想血管组织的局部肾素-血管紧张素系统( localrenin - angiotensinsystem ， l - ras )可能发挥重要局部调控作用。
The mosaic theory states that multiple factors sustain elevated bp even though an aberration of only one was initially responsible ; eg , the interaction between the sympathetic nervous system and the renin - angiotensin - aldosterone system 镶嵌理论认为，有多种因素使血压维持在升高位置，尽管最初起作用的异常因素只有一个，如交感神经系统和肾素-血管紧张素-醛固酮之间的相互作用。
Anp is a circulating hormone with asodilatory and diuretic properties that inhibits the renin - angiotensin - aldosterone system , which has been suggested to modulate cardiac sympathetic nere actiity and cardiac remodeling Anp是循环系统中的一种激素，其舒张血管和利尿特性能够抑制肾素?血管紧张素?醛固酮系统。普遍认为肾素?血管紧张素?醛固酮系统能够调节心脏交感神经活性和心脏重塑。
Our aim was to determine whether inhibitors of the renin - angiotensin - aldosterone system , which can reduce entricular hypertrophy and myocardial fibrosis , can improe diastolic function to a greater extent than can other antihypertensie agents 肾素-血管紧张素-醛固酮系统可以减小心室肥大和减少心肌纤维化，我们的目的就是确定这一系统的抑制剂是否比其它抗高血压药物能更好地改善心脏舒张功能。
Other mechanisms become involved when hypertension due to an identifiable cause ( eg , catecholamine release from a pheochromocytoma , renin and angiotensin from renal artery stenosis , aldosterone from an adrenal cortical adenoma ) has existed for some time 当因某些易于确定的原因所引起的高血压存在一段时间后，如嗜铬细胞瘤释放的儿茶酚胺、肾动脉狭窄所产生的肾素和血管紧张素、肾上腺皮质腺瘤分泌的醛固酮等，其他机制也会参与高血压病的形成。
Although angiotensin is generally acknowledged to be responsible for renovascular hypertension , at least in the early phase , there is no consensus regarding the role of the renin - angiotensin - aldosterone system in patients with primary hypertension , even in those with high pra 普遍认为，血管紧张素对肾血管性高血压负有责任，至少是在早期，但是，在原发性高血压病人，甚至是pra升高的原发性高血压病人中，人们对肾素-血管紧张素-醛固酮系统所起的作用尚无一致意见。
Combining the ace inhibitor and the arb , " which target different aspects of the renin angiotensin system , may hae merit in the treatment of both cardioascular and metabolic disease , which are characterized by reciprocal relationships between endothelial dysfunction and insulin resistance , " the inestigators conclude Ace抑制剂联合arb ， “针对肾素血管紧张素系统的不同方面，在治疗内皮功能障碍与胰岛素抵抗相互关联的心血管和代谢病方面有优势， ”研究人员得出结论。
Among antihypertensive measures , blockade of the raas by means of ace inhibitors or angiotensin ii receptor antagonists recently emerged as a potentially polyvalent approach , not only for treating hypertension and reducing cardiovascular events , but also to prevent or reduce albuminuria , counteract diabetic nephropathy and lower the occurrence of new type 2 diabetes in individuals at risk 在抗高血压药物治疗中，通过用ace抑制剂或血管紧张素受体拮抗剂可阻滞肾素-血管紧张素-醛固酮系统激活，最近其可作为一种潜在多能的治疗方法，不仅可治疗高血压和减少心血管事件，也能够预防或减少蛋白尿，阻止糖尿病性肾病变，并使新糖尿病患者发生风险性降得更低。
Renin secretion is controlled by at least four mechanisms that are not mutually exclusive : a renal vascular receptor responds to changes in tension in the afferent arteriolar wall ; a macula densa receptor detects changes in the delivery rate or concentration of nacl in the distal tubule ; circulating angiotensin has a negative feedback effect on renin secretion ; and the sympathetic nervous system stimulates renin secretion via the renal nerve mediated by receptors 肾素的分泌至少受四种互不排斥的机制控制：肾血管受体对向心小动脉壁张力变化的反应；致密斑受体发现远端肾小管内氯化钠传递速率或浓度的变化；循环的血管紧张素对肾素的分泌的负反馈效应；和交感神经系统经由受体介导的肾神经刺激分泌肾素。
