Success of the model was enhanced by increasing the oxygen concentration on initiation of the bypass , maintenance of an appropriate hematocrit and priming with non - citrated blood crystalloid 此模式是以藉著在启始?路时增加氧浓度，维持适当血球容积以及用无枸橼酸之血液晶质启动而使得本技术得以成功。
It is well known that in patients who suffer from starvation , chronic metabolic acidosis , chronic renal insufficiency , distal renal tubular acidosis and nephrolithiasis , the reabsorption of urinary citrate is increased and the excretion is decreased in kidney 研究表明，在饥饿、代谢性酸中毒、肾功能不全、远端肾小管酸中毒及肾结石患者中，肾脏对尿枸橼酸的重吸收增加，尿枸橼酸排泄减少。
The hnadcs ( human na + / dicarboxylate cotransporter 3 ) mediates the transport of krebs cycle intermediates , such as succinate , citrate and a - ketoglutarate , across the plasma membrane of many epithelial cells 人钠二羧酸协同转运蛋白3 ( humanna ~ + dicarboxylatecotransporter3 ， hnadc3 )基因的编码产物是位于多种上皮细胞膜表面的一类介导琥珀酸、枸橼酸及-酮戊二酸等三羧酸循环中间产物转运的蛋白。
