Decreased protein expression of placental egfr , influenced by the decrease of egfr gene transcript , was found in women with pih , and that may play a role in the pathogenesis of pih 妊高征胎盘滋养层细胞egfllillluva转录减少，最终导致egfr的蛋白质表达减少，影响其生物学作用。
Tha pathological changes in ultrastructure of placental tissues in study group were quite obvious . compared with that of normal pregnancy , the expression of egfr as well as egfrmrna in placenta from pregnancies complicated with pih decreased significantly ( p < 0 . 01 ) 妊高征组胎盘滋养层细胞超微结构有明显的病理学改变， egfr的表达低于对照组，差异有显著性（ p功
2 . to investigate the pathological changes in ultrastructure of placental tissues in patients with pregnancy induced hypertension ( pih ) and to clarify the expression of egfr and egfrmrna in placenta so as to discuss the pathogenesis of pih 观察妊高征胎盘滋养层细胞超微结构病理学改变，以及妊高征组胎盘滋养细胞egfr蛋白质的表达和egfrmrna的表达，并与正常妊娠组比较，探讨其发病机理。
Human trophoblast cells express both egf and egfr , and that egf plays a major role in placental implantation , growth and differentiation . an alteration of egfr biological activity directly interferes with the differentiated function and proliferation of trophoblast and the fetoplacental development Egfr的表达异常伴随着胎盘滋养层细胞的分化增殖以及功能的改变，本研究目的旨在直接阐述egfr在滋养层细胞分化发育中的作用，以及与妊高征、绒毛膜癌发病的关系。
The immunohistochemical method and western blot were preformed to show the expression of egfr and rt - pcr method was applied to determine the expression of egfr mrna in placenta trophoblast of pregnancy with pih . 3 . egfr of jar was determined by immunohistochemical method and egfrmrna was analyzed by rt - pcr method 电子显微镜观察正常妊娠及妊高征患者两组胎盘滋养细胞的超微结构，应用免疫组织化学方法及westernblot方法测定妊高征胎盘滋养层细胞表皮生长因子受体（ egfr ）的表达，以及rt一nr技术对egfrmrna进行定量分析。
