The identified proteins are involved in a variety of cellular process including several zinc finger proteins relevant to transcription regulation , such as zinc finger 198 , 263 , 14 , 224 , zf6 , novel protein similar to transcriptional represser ctcf , and kruppel - like zinc finger protein ; two members of the adams ( a disintegrin and metalloprotease domain ) family ; two members of integrin family ; several proteins involved in the signal transduction , cell - cycle control , chromatin remodeling and transcription repression ; and also some proteins of cell skeleton and some with unknown functions 鉴定出的蛋白包括多个与转录调控相关的锌指蛋白，如锌指蛋白198 、 263 、 14 、 224 、 zf6 、转录抑制因子ctcf样蛋白、幻肚pple样锌指蛋白等:两个含金属蛋白酶结构域和整合素结合结构域的家族成员adam28和adam17 ;两个整合素家族成员pz整合素和含十个egf样结构域的整合素( tied ) ;与细胞信号转导通路有关的蛋白;与细胞周期调控有关的蛋白;与染色体重塑和基因转录抑制有关的蛋白;细胞骨架蛋白以及其他功能未明的蛋白等。
The complete human znf325 cdna sequence is 2697bp and contains a 1389 - bp open reading frame ( orf ) that encodes a 462 amino acid protein with 15 zinc finger c2h2 motifs . the complete human znf359 cdna sequence is 3270bp and contains a 1932 - bp open read ing frame ( orf ) that encodes a 643 amino acid protein with an n - terminal krab domain and 16 c - terminus zinc finger c2h2 motifs . the zfp28 cdna sequence is 4104bp and contains a 2076 - bp open reading frame ( orf ) that encodes an 868 amino acid protein with an n - terminal signal peptide , two krab domains and 14 c - terminal c2h2 zinc finger motifs Znf325长2697个碱基，含有一个长为1389个碱基的开放阅读框，编码一个长为462个氨基酸的蛋白质，它包含15个c2h2型锌指结构； znf359长3270个碱基，含有一个长为1932个碱基的开放阅读框，编码一个长为643个氨基酸的蛋白质，它包含一个n -端krab结构域和16个c -端c2h2型锌指结构； zfp28长4104个碱基，含有一个长为2076个碱基的开放阅读框，编码一个长为868个氨基酸的蛋白质，它包含一个n -端信号肽，两个krab结构域和14个c -端c2h2型锌指结构。
The krupple type zinc finger motif found in many transcription factors is thought to be important for nucleic acid binding and / or dimerization . here we have identified and characterized two novel zinc finger genes named znf323 and znf360 using degenerate primers from an early human embryo heart cdna library 本文利用kr ppel型( cys _ 2 his _ 2型)锌指基因顺序上的保守特征，设计简并引物从人类早期胚胎cdna文库中初步筛选克隆出四个kr pple型锌指蛋白新基因，经国际基因命名委员会批准命名为znf323 、 znf360 、 znf359和zfp28 。
