The lowered glutathione values and increased oxidative stress are thought to be responsible for the loss of dopamine - producing cells in the substantia nigra in parkinson ' s disease patients ( 7 , 8 ) （研究7 , 8 ）认为谷胱甘肽含量减低和氧化压力的增加应是帕金森氏症病患脑部黑质层内失去制造多巴胺的细胞的原因。
In parkinson ' s disease nerve cells slowly degenerate in the part of the mid - brain ( the substantia nigra layer of the basal ganglia ) that controls movement , resulting in progressive loss of muscular co - ordination and balance 帕金森氏症患者的中脑（神经中枢底部的黑质层）控制行动部份的神经细胞慢慢退化，导致肌肉协调与平衡能力的逐步丧失。
A large number of neurons with nig - li were seen in the anterior olfactory nuclei , accumbens nucleus , septal area , 09600045 , 39970377 , 39570109 ) 9 ventral pallidum , pallidum , caudate putamen , nucleus of the stria terminalis , anterior hypothalamic area , tuber cinereum area , lateral hypothalamic area , perifornical nucleus , supraoptic nucleus , arcuate nucleus , mammillar nuclei , substatia nigra , ventral tegmental area , retrorubral area , superior and inferior colliculus , periaqueductal gray , nucleus of the solitary tract , and superficial layers of the medullary and spinal dorsal horns 大量nk3受体样免疫反应阳性神经元出现于前嗅核、伏隔核、隔区、腹侧苍白球、苍白球、尾壳核、终纹床核、下丘脑前区、下丘脑结节区、下丘脑外侧区、穹隆周区、视上核、弓状核、乳头体、黑质、腹侧被盖区、红核后区、上丘和下丘、导水管周围灰质、孤束核、及延髓和脊髓背角浅层。
When someone with a susceptible genetic background encounters certain environmental factors , such as pesticides or other chemicals [ see box on this page ] , the cells in that individual ' s substantia nigra suffer more stress and accumulate more misfolded proteins than do the same cells in other people 当易发病遗传体质的人碰了上某些环境因子，例如杀虫剂或其他化学物质（见右栏环境元凶） ，这些人的黑质神经元，会比其他人更容易受逆境所伤害，摺叠错误的蛋白质也堆积得更多。
Gonadal steroid hormone , especially estrogen , exerted considerable effects upon the pituitary , hypothalamus , nigrostriatal and mesolimbic dopaminergic ( daergic ) systems , of which , amygdala ( amy ) was one of the most important site affected by estrogen and the main projection site for daergic neurons from midbrain 大量研究证明，性腺类固醇激素可在垂体、下丘脑、黑质?纹状体系统和中脑边缘系统水平影响多巴胺( da )能神经元的功能。其中，杏仁核( amy )是雌激素的重要作用部位之一。
In the present study , in order to investigate the effects of endogenous estrogen on the daergic terminals in amy and the daergic neurons in midbrain , fast cyclic voltammetry ( fcv ) was used to examine da release evoked by electrical stimulation from amy of female rats in different phases of estrus cycle , ovx rats and male rats . and tyrosine hydroxylase ( th ) immunohistochemi stry was employed to measure the numbers of daergic neurons of ventral tegmental area ( vta ) and substantia nigra ( snc ) in the rats 因此，为进一步探讨大鼠内源性雌激素水平的变化对amyda能神经系统及中脑da能神经元的影响，本工作应用快速周期伏安法( fcv )在体监测了处于动情周期各期雌鼠、 ovx鼠和雄鼠经电刺激诱发的amyda释放，并应用酪氨酸羟化酶( th )免疫组化方法测定了以上各组大鼠腹侧背盖区( vta ) 、黑质( snc )的th阳性神经元数目。
