Glial cell line - derived neurotrophic factor ( gdnf ) was originally isolated based on its potent and specific ability to promote the survival and morphological differentiation of dopaminergic neurons and motoneurons in embryonic midbrain cultures . in addition , gdnf also support the survival and regulate the differentiation of many peripheral neurons , including sympathetic , parasympathetic , sensory and enteric neurons . gdnf also plays a crucial role outside the nervous system , as a morphogenetic factor in kidney development and as a regulator of spermatogonia differentiation Gfr 1与gdnf结合位点的研究胶质细胞源性神经营养因子( gdnf )对多巴胺能神经元、运动神经元、感觉神经元、肠道神经元等多种神经元具有促进存活及保护作用，它还能促进肾脏的发育和精原细胞的成熟，因此，极有希望用于治疗神经损伤和神经系统退行性病变。
There are a lot of problems to be studied in this field , but at present the matters of related diseases severely threatening human health , such as diabetes mellitus , cardiovascular diseases , cancer , neuropathic degenerative diseases , should be taken precedence 无机小分子与细胞生物大分子相互作用的研究内容非常丰富，目前应著重研究那些对人类有严重威胁的一些疾病如糖尿病、心血管病、肿瘤、神经退行性病变等有关的细胞无机化学中无机小分子与生物大分子相互作用的问题。
