The venom of the bird hunting spider selenocosmia huwena , with bodysize of 6 - 9cm , which distributes in southwestern hilly area of china and habitually lives in the holes underground , contains a mixture of compounds with different types of biological activity 虎纹捕鸟蛛( selenocosmiahuwena )是我国西南部山区发现的蜘蛛新种，属于捕鸟蛛科( theraphosidae ) 。该蛛穴居地下，个体大，毒性强。
Huwentoxin - i ( hwtx - i ) is a polypeptide neurotoxin isolated from the crude venom of chinese bird spider selenocosmia huwena . its molecular weight is 3750 dalton . the toxin contains 33 amino acid residues and three disulfide bonds 虎纹捕鸟蛛毒素- ( huwentoxin - )是从虎纹捕鸟蛛selenocosiahuwena粗毒中分离得到的一种多肽类神经毒素，分子量为3750 ，由33个氨基酸残基组成，含三对二硫键。
Huwentoxin xi ( hwtx ~ xi ) , a serine protease ! inhibitor , consists of 55 amino acid residues with three disulfide bridges . the toxin was isolated from the venom of the chinese spider ornithochoctonus huwena by ion - exchange chromatogram - phy and reverse phase high performance liquid chromatography 本文报道从虎纹捕鸟蛛( ornithochoctonushuwena )粗毒中，应用阳离子交换和反相高效液相色谱的方法分离到一种胰蛋白酶抑制剂，命名为huwentoxin - ( hwtx - ) 。
Abstract l : the chinese bird spider , ornithochoctonus huwena , distributed in the hilly areas of yunnan and guangxi in the south of china , was recently identified as a new species and is one of the most venomous spiders in china . in our previous work , we have demonstrated that 0 . huwena venom contains a mixture of compounds with different types of biological activities 它的粗毒中含有多种活性成分，其中研究的比较深入的多为神经毒素，如hwtx - ，这是一种突触前膜n型钙离子通道阻断剂；毒素hwtx - ，它是一种ttx敏感型钠离子通道阻断剂；另外，还从虎纹粗毒中纯化出一种具有凝集活性毒素成分shl - 。
Among them , selenocosmia huwena and selenocosmia hainana belong to theraphosidae while macrothele raveni belongs to hexathelidae . all of them could kill insects and some small vertebrate with their venoms . in this article , using whole - cell patch - clamp technology , we observed the effects of the venoms from the three kinds of spider on the voltage - activated tetrodotoxin - sensitive ( ttx - s ) sodium current and delay - rectified potassium current of undifferentiated ng108 - 15 cells 虎纹捕鸟蛛( selenocosmiahuwena ) 、海南捕鸟蛛( selenocosmiahainana )和雷氏大疣蛛( macrotheleraveni )均是在我国近年来发现的蜘蛛新种，前两者属于捕鸟蛛科，而后者属于异仿蛛科。
A neurotoxic peptide ( named huwentoxin - v ) was purified from the venom of the spider by a combination of ion exchange chromatography and reverse phase hplc . hwtx - v has 35 amino acid residues , with the molecular mass 4111 . 4da . the amino acid sequence has been determined as nh2 - ecrwylggcsqdgdcckhlqchsn - yewcvwdgtfs - cooh , which consists of 6 cys , formed three pairs of disulfide bridges 本文报道从虎纹捕鸟蛛( selenocoimahuwena )粗毒中，结合阳离子交换和反相高效液相色谱分离纯化出一种昆虫毒素，命名为虎纹捕鸟蛛毒素- ( huwentoxin - ， hwtx - ) ；其天然突变体( themutantofhuwentoxin ， mhwtx - )也同时纯化出来。
