[ b ] mancia : [ / b ] well ， no question that rennin inhibitors are a new class of agents ， promising agents 嗯，肾素抑制剂确实是一种新药，一种很有前景的药物。
In the renin - angiotensin - aldosterone system , the juxtaglomerular apparatus helps regulate volume and pressure 在肾素-血管紧张素-醛固酮系统中，肾小球旁体帮助调节血容量和压力。
If these would demonstrate that then there would be an even stronger rationale to use rennin inhibitors alone or in combination 如果这一点得到证实的话，那么我们就会更有理由在单独用药和联合治疗中使用肾素抑制剂了。
Plasma renin activity ( pra ) is usually normal in patients with primary hypertension but is suppressed in about 25 % and elevated in about 15 % 原发性高血压病人的血浆肾素活性( pra )通常是正常的，但约25 %受抑制，约15 %可能升高。
Alcohol also interferes with the liver s ability to metabolize hormones , such as renin and angiotensin , which are important for maintaining blood pressure control 酒精还干扰肝脏代谢激素如肾素和血管紧张素的能力，而这些激素对于保持血压正常是很重要的。
Sympathetic innervation of the juxtaglomerular apparatus in the kidney releases renin ; angiotensin stimulates autonomic centers in the brain to increase sympathetic discharge 肾脏肾小球旁体的交感神经支配释放肾素；血管紧张素刺激大脑自主中枢，增加交感冲动发放。
Renin , a proteolytic enzyme formed in the granules of the juxtaglomerular apparatus cells , catalyzes conversion of the protein angiotensinogen to angiotensin i , a decapeptide 肾素是肾小球旁体细胞颗粒内形成的一种蛋白水解酶，催化蛋白血管紧张素原转换为血管紧张素，即十肽。
It acts on one of the key regulators of blood pressure by targeting rennin ， and provides significant blood pressure reduction for a full 24 hours and is generally well tolerated 该药主要作用于肾素这个关键的血压调节器，并且能够提供持续24小时的显著降压效应，而且耐受性良好。
Buraczynska m , ksiazek p , lopatynski j , et al . association of the renin ? angiotensin system gene polymorphism with nephropathy in type diabetes [ j ] . pol arch med wewn , 2002 , 108 : 725 ? 730 吴松华，项坤三，郑泰山,等.肾素?血管紧张素系统三个关键基因与2型糖尿病肾病发病关系的研究[ j ] .中华内分泌代谢杂志, 2001 ， 17 ： 331 ? 334
The promise of these drugs is also connected to the fact that we hae begun to understand that rennin may hae effects independently on the formation of angiotensin ii to the traditional pathways 之所以说这种新药很有前景还有一部分原因是，我们已经开始懂得肾素对血管紧张素ii的形成有一定的作用，且这种作用不依赖于传统的作用途径。
