The cell - wall - mannan of c . albicans downregulate both il - 6 and il - 8 expression in human peripheral blood mononuclear cells : an in vitro study 白念珠菌胞壁溴化十六烷基三甲铵甘露聚糖下调白介素6和8的研究
Interleukin 6 is a chemical associated with bone metabolism and the immune response , and vitamin d synthesis is needed for strong healthy bones 白介素6是一种与骨骼代谢和免疫反应有关的化学物质，而维生素d是健康强壮的骨骼所不可或缺的。
Akahoshi m , nakashima h , tanaka y , et al . th1 / th2 balance of peripheral t helper cells in systemic lupus erythematosus [ j ] . arthritis rheum , 1999 , 42 : 1644 张红娟,王宗发,彭学标,等.系统性红斑狼疮患者血清白介素10水平与外周血单个核细胞分泌白介素12水平的关系[ j ]中华皮肤科杂志, 2001 , 34 : 287
On another day , the researchers tested the adult volunteers for proteins called c - reactive protein and interleukin six . other studies have linked the two proteins to heart disease and cancer 另一天，研究人员检测了成年志愿者的叫做c反应蛋白和细胞白介素6的蛋白质。有其它研究认为这两种蛋白和心脏病和癌症有关。
The annlic establishment gram clinical practice report has not borne the medicine phenomenon , also sudden change which to arab league past luo river wei gengxi luo river wei baijie induction and so on element produces is still sensitive Annlic安立克临床应用未报道耐药现象，且对阿昔洛韦更昔洛韦白介素等诱导产生的突变株依然敏感。
Sleep / waking cycle is a complex network modulation and many factors such as interleukin - 1 ( il - 1 ) , tumor necrosis factor ( tnf ) , growth hormone releasing hormone ( ghrh ) , vasoactive intestina polypeptide ( vip ) and many conventional neurotransmitters such as serotonin ( 5 - ht ) , acetylcholine ( ach ) , norepinephrine ( ne ) , dopamine ( da ) and gamma - aminobutyric acid ( gaba ) were involved in it . recent evidence has shown that no synthesized in neurons in several areas of the brain can induce the release of neurotransmitters . in the rat central nervous system , the anatomical distribution of nos - containing neurons is now well established , and it was reported that nos is co - localized with neurotransmitters well known for their involvement in sleep mechanisms , i . e . 5 - ht , ach , da and gaba 郑州大学2003届硕士毕业论文gaba受体激动剂消除no合成酶抑制剂对大鼠睡/醒周期的影响睡/醒周期的形成是一个复杂的网络调控的结果，体内许多因子都参与了这一调控网络，这些因子如白介素一1 ( il一1 ) 、肿瘤坏死因子( tnf ) 、生长激素释放激素( ghrh ) 、血管活性肠肤( vip )以及经典的神经递质如5一轻色氨( 5一ht ) 、乙酞胆碱( ach ) 、去甲肾上腺素( ne ) 、多巴胺( da )和卜氨基丁酸( gaba )等，它们在睡眠的发生和调节中也发挥着重要作用。
Our results showed as follows : 1 ) the spl and rsal polymorphisms of the collagen type 1 alpha 1 ( col1 al ) gene , the - 174g / c promoter polymorphism of the interleukin - 6 ( il - 6 ) gene , the asn363ser polymorphism of the glucocorticoid receptor ( gr ) gene , and the t ? c polymorphism in intron 5 of the transforming growth factor pi ( tgf - p ! ) gene are absent or too rare in chinese . compared the polymorphisms of these five markers with other populations using % 2 test and fisher ' s exact two - tailed test , significant differences of allele and genotype frequency distributions were observed at these polymorphisms ( p < 0 . 001 ) 结果表明： 1 )白介素6 ( il ? 6 )基因的? 174g c多态性、型胶原蛋白_ 1 ( col1a1 )基因的sp1和rsa多态性、转化生长因子_ ( tgf - _ 1 )基因的内含子5t c多态性和糖皮质激素受体( gr )基因的asn363ser的多态性在中国人群中均未发现或者多态性很低； x ~ 2检测和fisher精确(双尾)检验比较这些多态性的频率，发现在中国人群与其它种群或人群中，等位基因和基因型存在显著的差异( p 0 . 001 ) 。
Oligochitosan has been observed to upregulate the production of interleukin - l ( il - l ) , tumor necrosis factor - a ( tnf - a ) , granulocyte macrophage colony stimylating factor ( gmcsf ) , interleukin - 6 ( il - 6 ) by macrophage and induce immunologic adjuvant effects . many aspects of oligochitosan ' s functions have been discovered by researchers , but the mechanism is still unclear 整体动物实验表明壳寡糖能激活巨噬细胞，增强巨噬细胞的杀伤活性，诱导如白介素- 1 ( il - 1 ) 、肿瘤坏死因子( tnf - ) 、粒单核集落刺激因子( gm - csf ) 、白介素- 6 ( il - 6 )等细胞因子的分泌，增加t细胞和nk细胞的活性。
3 ) we tested total - family association , within - family association ( via tdt ) , and linkage , between the bsrbl marker and bone phenotypes ( bmd and bone size ) at the spine and the hip ( femoral neck , torchanter and intertrochanter ) in chinese 402 nuclear families with a total number of 1263 , and found the suggestive linkage ( p - 0 . 037 ) between the il - 6 bsrbl maker and the li _ 4 spine bmd . no significant association and linkage was found for bone size and hip bmd . the present studies represented molecular genetic research of bone mineral density , and identified some factors related to bmd in chinese 3 )在征集的402个核心家庭包括1263个个体组成的上海样本中，利用传递不平衡检测法( tdt ) 、关联分析和连锁分析，检测了白介素6基因和不同骨骼位点(腰椎、股骨颈、大转子、转子间区)的骨密度、骨大小之间的连锁和/或关联关系，并发现白介素6基因的bsrb工标记和控制腰椎骨密度的数量性状位点( qtl )之间存在连锁的证据( p = 0 . 037 ) 。
