Abstract : this article is mainly concerned about the mechanism , preparation and characteristics of the drug release in vitro and in vivo of the controlled - release suspensions using ion - exchange resins . various resins ' abilities of adsorption and release of drug were compared . the method of microencapsulating drug - resin complex and the effect of various coating materials were also discussed 文摘:介绍了离子交换树脂控释混悬剂的原理、制备、释药动力学和体内释放特点，并对不同树脂吸附和释放药物的能力进行了比较，同时也介绍了微囊化包衣技术及不同包衣材料对树脂释放药物的影响
Studies of the crystal structure of endostatin have shown a compact globular fold , with one face particularly rich in arginine residues acting as a heparin - binding epitope , this site was recently shown to be involved in the inhibition of induced angiogenesis . experimental studies show that recombinant endostatin specifically inhibits the proliferation of endothelial cells in a dosedependent fashion . recombinant endostatin from bacteria is largely insoluble , but still efficient in arresting tu mor growth after injection into mice . intermittent therapy with recombinant bacterially produced endostatin reduces several experimental tumors , including lewis lung carcinoma , to a dormant state . no sign of drug induced resistance has been reported and , in the original study , the treatment dormancy appeared to persist even when therapy was discontinued . sowe regard endostatin as a promising anti - tumor drug 许多研究表明重组内皮抑素特异性抑制内皮细胞增殖，而且这种抑制作用呈剂量依赖性。细菌表达产物内皮抑素大部分以不溶形式存在，将这种混悬液注射治疗老鼠仍可以抑制肿瘤生长。于小鼠皮下重复注射内皮抑素重组蛋白，几乎完全抑制鼠lewis肺癌等多种肿瘤生长，并无耐药性产生，即使中断治疗肿瘤也不再复发。
( 3 ) left lower limb was used to prepare artery ( red ) and vein ( blue ) color cast specimens using perchloroethylene . ( 4 ) deep freezed right lower limb sample , injecting red gelatin into femoral artery , forward and backward injecting blue latex with barium sulfate into femoral vein and great saphenous vein , cuting flap after dealing with formalin and get x - ray photos ( 3 )采用1例新鲜尸体左下肢标本制备过氯乙烯动(红) 、静(蓝)脉分色铸型标本。 ( 4 )右下肢冷藏标本，于股动脉灌注红色乳胶，再于股静脉及大隐静脉顺、逆行灌注含硫酸钡混悬液之蓝色乳胶，福尔马林防腐，然后切取皮瓣，摄取x线片。
